The Prognostic and Clinical Value of Tumor-Associated Macrophages in Patients With Breast Cancer: A Systematic Review and Meta-Analysis

BackgroundThe prognostic and clinical value of tumor-associated macrophages (TAMs) in patients with breast cancer (BCa) remains unclear. We conducted the current meta-analysis to systematically evaluate the association of CD68+ and CD163+ TAM density with the prognosis and clinicopathologic features...

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Bibliographic Details
Published in:Frontiers in oncology 2022-06, Vol.12, p.905846-905846
Main Authors: Wang, Changjun, Lin, Yan, Zhu, Hanjiang, Zhou, Yidong, Mao, Feng, Huang, Xin, Sun, Qiang, Li, Chenggang
Format: Article
Language:English
Subjects:
breast cancer
meta-analysis
Oncology
survival
systematic review
tumor-associated macrophages
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Summary:BackgroundThe prognostic and clinical value of tumor-associated macrophages (TAMs) in patients with breast cancer (BCa) remains unclear. We conducted the current meta-analysis to systematically evaluate the association of CD68+ and CD163+ TAM density with the prognosis and clinicopathologic features of BCa patients. MethodsSearches of Web of Science, PubMed, and EMBASE databases were performed up to January 31, 2022. The meta-analysis was conducted using hazard risks (HRs) and 95% confidence intervals (CIs) for survival data including overall survival (OS), disease-free survival (DFS), and BCa specific survival. Sensitivity and meta-regression analyses were also conducted to identify the robustness of the pooled estimates. ResultsOur literature search identified relevant articles involving a total of 8,496 patients from 32 included studies. Our analysis indicates that a high CD68+ TAM density in the tumor stoma was significantly linked with poor OS (HR 2.46, 95% CI, 1.83-3.31, P
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.905846