Unveiling the Significance of Peroxiredoxin 6 in Central Nervous System Disorders

Peroxiredoxin 6 (Prdx6), a unique 1-Cys member of the peroxiredoxin family, exhibits peroxidase activity, phospholipase activity, and lysophosphatidylcholine acyltransferase (LPCAT) activity. Prdx6 has been known to be an important enzyme for the maintenance of lipid peroxidation repair, cellular me...

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Bibliographic Details
Published in:Antioxidants 2024-04, Vol.13 (4), p.449
Main Authors: Xue, Min, Huang, Xiaojie, Zhu, Tong, Zhang, Lijun, Yang, Hao, Shen, Yuxian, Feng, Lijie
Format: Article
Language:English
Subjects:
1-Acylglycerophosphocholine O-acyltransferase
Acyltransferase
Amino acids
Antioxidants
Brain research
Central nervous system
Cysteine
Disease
Enzymatic activity
Enzymes
glutathione peroxidase
Homeostasis
Inflammation
Lipid metabolism
Lipid peroxidation
Lipids
Lysophosphatidylcholine
Nervous system diseases
neurodegeneration
neuroinflammation
Neurological diseases
Oxidative stress
Peroxiredoxin
phospholipase A2
Phospholipids
Physiological aspects
Physiology
Prdx6
Proteins
Spinal cord
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Summary:Peroxiredoxin 6 (Prdx6), a unique 1-Cys member of the peroxiredoxin family, exhibits peroxidase activity, phospholipase activity, and lysophosphatidylcholine acyltransferase (LPCAT) activity. Prdx6 has been known to be an important enzyme for the maintenance of lipid peroxidation repair, cellular metabolism, inflammatory signaling, and antioxidant damage. Growing research has demonstrated that the altered activity of this enzyme is linked with various pathological processes including central nervous system (CNS) disorders. This review discusses the distinctive structure, enzyme activity, and function of Prdx6 in different CNS disorders, as well as emphasizing the significance of Prdx6 in neurological disorders.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13040449