Disentangling age, gender, and racial/ethnic disparities in multiple myeloma burden: a modeling study

Multiple myeloma (MM) is a hematological malignancy that is consistently preceded by an asymptomatic condition, monoclonal gammopathy of undetermined significance (MGUS). Disparities by age, gender, and race/ethnicity in both MGUS and MM are well-established. However, it remains unclear whether thes...

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Bibliographic Details
Published in:Nature communications 2023-09, Vol.14 (1), p.5768-8, Article 5768
Main Authors: Huber, John H., Ji, Mengmeng, Shih, Yi-Hsuan, Wang, Mei, Colditz, Graham, Chang, Su-Hsin
Format: Article
Language:English
Subjects:
692/4028/67/2324
692/699/67/1990/804
692/700/478/174
Asymptomatic Diseases
Benign monoclonal gammopathy
Ethnicity
Gender
Health disparities
Health Status Disparities
Hematologic Neoplasms
Humanities and Social Sciences
Humans
Malignancy
Mathematical models
Minority & ethnic groups
Monoclonal Gammopathy of Undetermined Significance
multidisciplinary
Multiple myeloma
Multiple Myeloma - epidemiology
Race
Racial Groups
Risk groups
Science
Science (multidisciplinary)
Sex Factors
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Description
Summary:Multiple myeloma (MM) is a hematological malignancy that is consistently preceded by an asymptomatic condition, monoclonal gammopathy of undetermined significance (MGUS). Disparities by age, gender, and race/ethnicity in both MGUS and MM are well-established. However, it remains unclear whether these disparities can be explained by increased incidence of MGUS and/or accelerated progression from MGUS to MM. Here, we fit a mathematical model to nationally representative data from the United States and showed that the difference in MM incidence can be explained by an increased incidence of MGUS among male and non-Hispanic Black populations. We did not find evidence showing differences in the rate of progression from MGUS to MM by either gender or race/ethnicity. Our results suggest that screening for MGUS among high-risk groups (e.g., non-Hispanic Black men) may hold promise as a strategy to reduce the burden and MM health disparities. Multiple myeloma (MM) is a haematological malignancy that is preceded by monoclonal gammopathy of undetermined significance (MGUS). Here, the authors use a mechanistic model fitted to surveillance data from the United States to investigate whether variation in MM is best explained by incidence of MGUS or rate of progression to MM.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-41223-8