Feasibility study on the introduction of Micro-CT technology for the identification of Radix Bupleuri and its adulterants

, a kind of Chinese herbal medicine with great clinical use, is often confused with its adulterants, and it is difficult to identify it without certain knowledge. The existing identification methods have their own drawbacks, so a new method is needed to realize the identification of and its adultera...

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Bibliographic Details
Published in:Frontiers in pharmacology 2024-02, Vol.15, p.1347316-1347316
Main Authors: Chen, Kehong, Chen, Gong, Zhuang, Zhelong, Luo, Shouhua, Liu, Jiaming, Liu, Guorong
Format: Article
Language:English
Subjects:
3D reconstruction
data augmentation
identification
Micro-CT technology
microstructure
Pharmacology
Radix Bupleuri
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Summary:, a kind of Chinese herbal medicine with great clinical use, is often confused with its adulterants, and it is difficult to identify it without certain knowledge. The existing identification methods have their own drawbacks, so a new method is needed to realize the identification of and its adulterants. We used Micro Computed Tomography (Micro-CT) to perform tomography scans on and its adulterants, performed data screening and data correction on the obtained DICOM images, and then applied 3D reconstruction, data augmentation, and ResNext deep learning model for the classification study. The DICOM images after data screening, data correction, and 3D reconstruction can observe the differences in the microstructure of and its adulterants, thus enabling effective classification and analysis. Meanwhile, the accuracy of classification using the ResNext model reached 75%. The results of this study showed that Micro-CT technology is feasible for the authentication of . The pre-processed and 3D reconstructed tomographic images clearly show the microstructure and the difference between and its adulterants without damaging the internal structure of the samples. This study concludes that Micro-CT technology provides important technical support for the reliable identification of and its adulterants, which is expected to play an important role in the quality control and clinical application of herbs.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1347316