Anti-inflammatory and antinociceptive features of Bryonia alba L.: As a possible alternative in treating rheumatism

species have traditionally been used as a diuretic and laxative, to reduce edema and relieve joint pain. roots are used especially to treat rheumatic pain and applied to painful joints in Turkish folk medicine. roots were extracted with -hexane, ethyl acetate (EtOAc), and methanol, successively. The...

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Bibliographic Details
Published in:Open Chemistry 2019-01, Vol.17 (1), p.23-30
Main Authors: Ilhan, Mert, Dereli, Fatma Tuğçe Gürağaç, Tümen, Ibrahim, Akkol, Esra Küpeli
Format: Article
Language:English
Subjects:
Anti-inflammatory
antinociceptive
bryonia alba
Cucurbitaceae
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Summary:species have traditionally been used as a diuretic and laxative, to reduce edema and relieve joint pain. roots are used especially to treat rheumatic pain and applied to painful joints in Turkish folk medicine. roots were extracted with -hexane, ethyl acetate (EtOAc), and methanol, successively. The carrageenan-induced hind paw edema model and the Whittle method were used to evaluate the anti-inflammatory activity of the extracts in mice. The -benzoquinone-induced abdominal constriction test and tail flick test were used to evaluate the antinociceptive activity of the extracts in mice. DPPH-radical-scavenging activity, ABTS radical–scavenging activity, total antioxidant activity, and hydroxyl radical– scavenging activity were assessed. Furthermore, the total phenolic and total flavonoid contents were calculated for all the extracts. The EtOAc extract prepared from roots had the most promising anti-inflammatory, antinociceptive, and antioxidant activities. Moreover, it had high phenolic and flavonoid contents. Therefore, roots could be alternative treatment method for rheumatic disorders.
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2019-0003