Individualized event structure drives individual differences in whole-brain functional connectivity

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2022-05, Vol.252, p.118993-118993, Article 118993
• Main Authors: Betzel, Richard F., Cutts, Sarah A., Greenwell, Sarah, Faskowitz, Joshua, Sporns, Olaf
• Format: Article
• Language: English
• Subjects: Brain; Brain architecture; Brain Mapping - methods; Cognitive ability; Correlation of Data; Humans; Hypotheses; Individuality; Magnetic Resonance Imaging - methods; Nerve Net - diagnostic imaging; Neural networks; Time series
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2022.118993

Resting-state functional connectivity is typically modeled as the correlation structure of whole-brain regional activity. It is studied widely, both to gain insight into the brain's intrinsic organization but also to develop markers sensitive to changes in an individual's cognitive, clinical, and developmental state. Despite this, the origins and drivers of functional connectivity, especially at the level of densely sampled individuals, remain elusive. Here, we leverage novel methodology to decompose functional connectivity into its precise framewise contributions. Using two dense sampling datasets, we investigate the origins of individualized functional connectivity, focusing specifically on the role of brain network “events” – short-lived and peaked patterns of high-amplitude cofluctuations. Here, we develop a statistical test to identify events in empirical recordings. We show that the patterns of cofluctuation expressed during events are repeated across multiple scans of the same individual and represent idiosyncratic variants of template patterns that are expressed at the group level. Lastly, we propose a simple model of functional connectivity based on event cofluctuations, demonstrating that group-averaged cofluctuations are suboptimal for explaining participant-specific connectivity. Our work complements recent studies implicating brief instants of high-amplitude cofluctuations as the primary drivers of static, whole-brain functional connectivity. Our work also extends those studies, demonstrating that cofluctuations during events are individualized, positing a dynamic basis for functional connectivity.