The genetics of spatiotemporal variation in cortical thickness in youth

Prior studies have shown strong genetic effects on cortical thickness (CT), structural covariance, and neurodevelopmental trajectories in childhood and adolescence. However, the importance of genetic factors on the induction of spatiotemporal variation during neurodevelopment remains poorly understo...

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Bibliographic Details
Published in:Communications biology 2024-10, Vol.7 (1), p.1301-12, Article 1301
Main Authors: Schmitt, J. Eric, Alexander-Bloch, Aaron, Seidlitz, Jakob, Raznahan, Armin, Neale, Michael C.
Format: Article
Language:English
Subjects:
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Adolescent
Adolescents
Axonal transport
Biomedical and Life Sciences
Brain Cortical Thickness
Cell culture
Cerebral Cortex - anatomy & histology
Cerebral Cortex - diagnostic imaging
Child
Child development
Children
Dendrites
Female
Genetic diversity
Genetic factors
Genetics
Humans
Life Sciences
Longitudinal Studies
Magnetic Resonance Imaging
Male
Neurodevelopment
Potassium
Potassium channels
Statistical analysis
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Summary:Prior studies have shown strong genetic effects on cortical thickness (CT), structural covariance, and neurodevelopmental trajectories in childhood and adolescence. However, the importance of genetic factors on the induction of spatiotemporal variation during neurodevelopment remains poorly understood. Here, we explore the genetics of maturational coupling by examining 308 MRI-derived regional CT measures in a longitudinal sample of 677 twins and family members. We find dynamic inter-regional genetic covariation in youth, with the emergence of regional subnetworks in late childhood and early adolescence. Three critical neurodevelopmental epochs in genetically-mediated maturational coupling were identified, with dramatic network strengthening near eleven years of age. These changes are associated with statistically-significant (empirical p-value
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-024-06956-2