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The genetics of spatiotemporal variation in cortical thickness in youth
Prior studies have shown strong genetic effects on cortical thickness (CT), structural covariance, and neurodevelopmental trajectories in childhood and adolescence. However, the importance of genetic factors on the induction of spatiotemporal variation during neurodevelopment remains poorly understo...
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| Published in: | Communications biology 2024-10, Vol.7 (1), p.1301-12, Article 1301 |
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| creator | Schmitt, J. Eric Alexander-Bloch, Aaron Seidlitz, Jakob Raznahan, Armin Neale, Michael C. |
| description | Prior studies have shown strong genetic effects on cortical thickness (CT), structural covariance, and neurodevelopmental trajectories in childhood and adolescence. However, the importance of genetic factors on the induction of spatiotemporal variation during neurodevelopment remains poorly understood. Here, we explore the genetics of maturational coupling by examining 308 MRI-derived regional CT measures in a longitudinal sample of 677 twins and family members. We find dynamic inter-regional genetic covariation in youth, with the emergence of regional subnetworks in late childhood and early adolescence. Three critical neurodevelopmental epochs in genetically-mediated maturational coupling were identified, with dramatic network strengthening near eleven years of age. These changes are associated with statistically-significant (empirical p-value |
| doi_str_mv | 10.1038/s42003-024-06956-2 |
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Schmitt et al. studied the genetics of maturational coupling via longitudinal models of cortical thickness in N=677. Genetic correlations were dynamic. Patterns resembled expression of genes associated with potassium channels and dendrite formation.</description><identifier>ISSN: 2399-3642</identifier><identifier>EISSN: 2399-3642</identifier><identifier>DOI: 10.1038/s42003-024-06956-2</identifier><identifier>PMID: 39390064</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>38/39 ; 59/57 ; 631/208/1515 ; 631/378/116/2393 ; 692/698/1688/64 ; Adolescent ; Adolescents ; Axonal transport ; Biomedical and Life Sciences ; Brain Cortical Thickness ; Cell culture ; Cerebral Cortex - anatomy & histology ; Cerebral Cortex - diagnostic imaging ; Child ; Child development ; Children ; Dendrites ; Female ; Genetic diversity ; Genetic factors ; Genetics ; Humans ; Life Sciences ; Longitudinal Studies ; Magnetic Resonance Imaging ; Male ; Neurodevelopment ; Potassium ; Potassium channels ; Statistical analysis</subject><ispartof>Communications biology, 2024-10, Vol.7 (1), p.1301-12, Article 1301</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c366t-b55cdf9c7b29ae72b81b1721974bb5a5ed96d6e5bfb27daf2411189f49ab9123</cites><orcidid>0000-0002-5622-1190 ; 0000-0003-4887-659X ; 0000-0002-7487-227X ; 0000-0002-8164-7476 ; 0000-0001-6554-1893</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/3115237973?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39390064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmitt, J. Eric</creatorcontrib><creatorcontrib>Alexander-Bloch, Aaron</creatorcontrib><creatorcontrib>Seidlitz, Jakob</creatorcontrib><creatorcontrib>Raznahan, Armin</creatorcontrib><creatorcontrib>Neale, Michael C.</creatorcontrib><title>The genetics of spatiotemporal variation in cortical thickness in youth</title><title>Communications biology</title><addtitle>Commun Biol</addtitle><addtitle>Commun Biol</addtitle><description>Prior studies have shown strong genetic effects on cortical thickness (CT), structural covariance, and neurodevelopmental trajectories in childhood and adolescence. However, the importance of genetic factors on the induction of spatiotemporal variation during neurodevelopment remains poorly understood. Here, we explore the genetics of maturational coupling by examining 308 MRI-derived regional CT measures in a longitudinal sample of 677 twins and family members. We find dynamic inter-regional genetic covariation in youth, with the emergence of regional subnetworks in late childhood and early adolescence. Three critical neurodevelopmental epochs in genetically-mediated maturational coupling were identified, with dramatic network strengthening near eleven years of age. These changes are associated with statistically-significant (empirical p-value <0.0001) increases in network strength as measured by average clustering coefficient and assortativity. We then identify genes from the Allen Human Brain Atlas with similar co-expression patterns to genetically-mediated structural covariation in children. This set was enriched for genes involved in potassium transport and dendrite formation. Genetically-mediated CT-CT covariance was also strongly correlated with expression patterns for genes located in cells of neuronal origin.
Schmitt et al. studied the genetics of maturational coupling via longitudinal models of cortical thickness in N=677. Genetic correlations were dynamic. Patterns resembled expression of genes associated with potassium channels and dendrite formation.</description><subject>38/39</subject><subject>59/57</subject><subject>631/208/1515</subject><subject>631/378/116/2393</subject><subject>692/698/1688/64</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Axonal transport</subject><subject>Biomedical and Life Sciences</subject><subject>Brain Cortical Thickness</subject><subject>Cell culture</subject><subject>Cerebral Cortex - anatomy & histology</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Child</subject><subject>Child development</subject><subject>Children</subject><subject>Dendrites</subject><subject>Female</subject><subject>Genetic diversity</subject><subject>Genetic factors</subject><subject>Genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Longitudinal Studies</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neurodevelopment</subject><subject>Potassium</subject><subject>Potassium channels</subject><subject>Statistical analysis</subject><issn>2399-3642</issn><issn>2399-3642</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kU9P3DAQxa2KqiDKF-ihitQLl7T-750jQkCRkHrZu2Un491ss_FiJ5X49jgbSlEPnMZ6_s2bGT1CvjD6nVGx-pElp1TUlMuaalC65h_IGRcAtdCSn7x5n5KLnHeUUgYAWshP5FSAAEq1PCN36y1WGxxw7JpcxVDlgxu7OOL-EJPrqz8udbMwVN1QNTEVrKjjtmt-D5jzrD7Fadx-Jh-D6zNevNRzsr69WV__rB9-3d1fXz3UjdB6rL1STRugMZ6DQ8P9inlmOAMjvVdOYQu61ah88Ny0LnDJGFtBkOA8MC7Oyf1i20a3s4fU7V16stF19ijEtLFu3rFHKzSY0K7QB2mkcxQwOI0OpAcptVHF63LxOqT4OGEe7b7LDfa9GzBO2QrGlKLUKFnQb_-huziloRx6pLgwYESh-EI1KeacMLwuyKidQ7NLaLaEZo-h2fmiry_Wk99j-9ryN6ICiAXI5WvYYPo3-x3bZ3aSoUI</recordid><startdate>20241010</startdate><enddate>20241010</enddate><creator>Schmitt, J. 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Eric</au><au>Alexander-Bloch, Aaron</au><au>Seidlitz, Jakob</au><au>Raznahan, Armin</au><au>Neale, Michael C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The genetics of spatiotemporal variation in cortical thickness in youth</atitle><jtitle>Communications biology</jtitle><stitle>Commun Biol</stitle><addtitle>Commun Biol</addtitle><date>2024-10-10</date><risdate>2024</risdate><volume>7</volume><issue>1</issue><spage>1301</spage><epage>12</epage><pages>1301-12</pages><artnum>1301</artnum><issn>2399-3642</issn><eissn>2399-3642</eissn><abstract>Prior studies have shown strong genetic effects on cortical thickness (CT), structural covariance, and neurodevelopmental trajectories in childhood and adolescence. However, the importance of genetic factors on the induction of spatiotemporal variation during neurodevelopment remains poorly understood. Here, we explore the genetics of maturational coupling by examining 308 MRI-derived regional CT measures in a longitudinal sample of 677 twins and family members. We find dynamic inter-regional genetic covariation in youth, with the emergence of regional subnetworks in late childhood and early adolescence. Three critical neurodevelopmental epochs in genetically-mediated maturational coupling were identified, with dramatic network strengthening near eleven years of age. These changes are associated with statistically-significant (empirical p-value <0.0001) increases in network strength as measured by average clustering coefficient and assortativity. We then identify genes from the Allen Human Brain Atlas with similar co-expression patterns to genetically-mediated structural covariation in children. This set was enriched for genes involved in potassium transport and dendrite formation. Genetically-mediated CT-CT covariance was also strongly correlated with expression patterns for genes located in cells of neuronal origin.
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| subjects | 38/39 59/57 631/208/1515 631/378/116/2393 692/698/1688/64 Adolescent Adolescents Axonal transport Biomedical and Life Sciences Brain Cortical Thickness Cell culture Cerebral Cortex - anatomy & histology Cerebral Cortex - diagnostic imaging Child Child development Children Dendrites Female Genetic diversity Genetic factors Genetics Humans Life Sciences Longitudinal Studies Magnetic Resonance Imaging Male Neurodevelopment Potassium Potassium channels Statistical analysis |
| title | The genetics of spatiotemporal variation in cortical thickness in youth |
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