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Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations
The family with sequence similarity 72 Member A (FAM72A) is overexpressed in several types of cancer. However, its contributions to tumorigenesis remain largely unknown. Based on The Cancer Genome Atlas (TCGA) database, FAM72A was upregulated across 33 types of cancer. Accordingly, high levels of FA...
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Published in: | International journal of molecular sciences 2022-12, Vol.24 (1), p.375 |
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description | The family with sequence similarity 72 Member A (FAM72A) is overexpressed in several types of cancer. However, its contributions to tumorigenesis remain largely unknown. Based on The Cancer Genome Atlas (TCGA) database, FAM72A was upregulated across 33 types of cancer. Accordingly, high levels of FAM72A predicted inferior outcomes in half of the cancer types using survival analysis (the Kaplan-Meier curve and univariate Cox regression model). Receiver operating characteristic (ROC) analysis demonstrated that FAM72A showed high accuracy in distinguishing cancerous tissues from normal ones. FAM72A was correlated with immune and stromal scores and immune cell infiltrations in various tumors. Moreover, FAM72A was also associated with tumor mutation burden (TMB), microsatellite instability (MSI), and immune checkpoint genes. Immunophenoscore (IPS) further validated that the FAM72A
tumor showed high immunogenicity and tended to respond to anti-PD1/PDL1/PDL2, anti-CTLA4 treatment, and combined immunotherapies. We also investigated the functional role of FAM72A in lung adenocarcinoma (LUAD). In vitro studies demonstrated that the ectopic expression of FAM72A accelerated the proliferation and migration of NSCLC cells, whereas silencing FAM72A showed the opposite effects on them. In short, FAM72A had prognostic potential and correlated with tumor immunogenicity in various tumors. Functional analysis indicated that FAM72A is an oncogene in LUAD. |
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tumor showed high immunogenicity and tended to respond to anti-PD1/PDL1/PDL2, anti-CTLA4 treatment, and combined immunotherapies. We also investigated the functional role of FAM72A in lung adenocarcinoma (LUAD). In vitro studies demonstrated that the ectopic expression of FAM72A accelerated the proliferation and migration of NSCLC cells, whereas silencing FAM72A showed the opposite effects on them. In short, FAM72A had prognostic potential and correlated with tumor immunogenicity in various tumors. Functional analysis indicated that FAM72A is an oncogene in LUAD.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24010375</identifier><identifier>PMID: 36613817</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Adenocarcinoma of Lung - immunology ; Carcinogenesis ; Carcinoma, Non-Small-Cell Lung - immunology ; FAM72A ; Humans ; LUAD ; Lung Neoplasms - immunology ; Membrane Proteins ; Neoplasm Proteins ; pan-cancer ; Prognosis ; tumor microenvironment</subject><ispartof>International journal of molecular sciences, 2022-12, Vol.24 (1), p.375</ispartof><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-d4b670a63b112e0ecd4001f5722cab3b1a774a6c4c175a7bc0ba894c5ee66e113</citedby><cites>FETCH-LOGICAL-c450t-d4b670a63b112e0ecd4001f5722cab3b1a774a6c4c175a7bc0ba894c5ee66e113</cites><orcidid>0000-0002-7021-1298 ; 0000-0002-6769-5121 ; 0000-0002-0408-3101</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820597/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820597/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36613817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bai, Yuwen</creatorcontrib><creatorcontrib>Cao, Kui</creatorcontrib><creatorcontrib>Zhang, Ping</creatorcontrib><creatorcontrib>Ma, Jianqun</creatorcontrib><creatorcontrib>Zhu, Jinhong</creatorcontrib><title>Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The family with sequence similarity 72 Member A (FAM72A) is overexpressed in several types of cancer. However, its contributions to tumorigenesis remain largely unknown. Based on The Cancer Genome Atlas (TCGA) database, FAM72A was upregulated across 33 types of cancer. Accordingly, high levels of FAM72A predicted inferior outcomes in half of the cancer types using survival analysis (the Kaplan-Meier curve and univariate Cox regression model). Receiver operating characteristic (ROC) analysis demonstrated that FAM72A showed high accuracy in distinguishing cancerous tissues from normal ones. FAM72A was correlated with immune and stromal scores and immune cell infiltrations in various tumors. Moreover, FAM72A was also associated with tumor mutation burden (TMB), microsatellite instability (MSI), and immune checkpoint genes. Immunophenoscore (IPS) further validated that the FAM72A
tumor showed high immunogenicity and tended to respond to anti-PD1/PDL1/PDL2, anti-CTLA4 treatment, and combined immunotherapies. We also investigated the functional role of FAM72A in lung adenocarcinoma (LUAD). In vitro studies demonstrated that the ectopic expression of FAM72A accelerated the proliferation and migration of NSCLC cells, whereas silencing FAM72A showed the opposite effects on them. In short, FAM72A had prognostic potential and correlated with tumor immunogenicity in various tumors. Functional analysis indicated that FAM72A is an oncogene in LUAD.</description><subject>Adenocarcinoma of Lung - immunology</subject><subject>Carcinogenesis</subject><subject>Carcinoma, Non-Small-Cell Lung - immunology</subject><subject>FAM72A</subject><subject>Humans</subject><subject>LUAD</subject><subject>Lung Neoplasms - immunology</subject><subject>Membrane Proteins</subject><subject>Neoplasm Proteins</subject><subject>pan-cancer</subject><subject>Prognosis</subject><subject>tumor microenvironment</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkc1v1DAQxS0EoqVw44xy5EBg_J1ckFarLqxURA_ACcmaOM7iVWIvdoLEf4-3W6rtyePxe78Z6xHymsJ7zlv44PdTZgIocC2fkEsqGKsBlH56Vl-QFznvARhnsn1OLrhSlDdUX5KftynuQsyztxWGvtpO0xLiGHfe4lhuh7EUs48hV3GoNqsvmq0qH6pbDPUag3XpzrZZgj2qiucHjr4_WV6SZwOO2b26P6_I9831t_Xn-ubrp-16dVNbIWGue9EpDah4Rylz4GwvAOggNWMWu9JFrQUqKyzVEnVnocOmFVY6p5SjlF-R7YnbR9ybQ_ITpr8mojd3jZh2BlP54egMV621oMoAKDwpWt4PTd8oVJIOII6sjyfWYekm11sX5oTjI-jjl-B_mV38Y9qGgWx1Aby9B6T4e3F5NpPP1o0jBheXbJhWtG2o0rxI352kNsWckxsexlAwx3DNebhF_uZ8tQfx_zT5P6kNoCM</recordid><startdate>20221226</startdate><enddate>20221226</enddate><creator>Bai, Yuwen</creator><creator>Cao, Kui</creator><creator>Zhang, Ping</creator><creator>Ma, Jianqun</creator><creator>Zhu, Jinhong</creator><general>MDPI</general><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-7021-1298</orcidid><orcidid>https://orcid.org/0000-0002-6769-5121</orcidid><orcidid>https://orcid.org/0000-0002-0408-3101</orcidid></search><sort><creationdate>20221226</creationdate><title>Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations</title><author>Bai, Yuwen ; Cao, Kui ; Zhang, Ping ; Ma, Jianqun ; Zhu, Jinhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-d4b670a63b112e0ecd4001f5722cab3b1a774a6c4c175a7bc0ba894c5ee66e113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adenocarcinoma of Lung - immunology</topic><topic>Carcinogenesis</topic><topic>Carcinoma, Non-Small-Cell Lung - immunology</topic><topic>FAM72A</topic><topic>Humans</topic><topic>LUAD</topic><topic>Lung Neoplasms - immunology</topic><topic>Membrane Proteins</topic><topic>Neoplasm Proteins</topic><topic>pan-cancer</topic><topic>Prognosis</topic><topic>tumor microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bai, Yuwen</creatorcontrib><creatorcontrib>Cao, Kui</creatorcontrib><creatorcontrib>Zhang, Ping</creatorcontrib><creatorcontrib>Ma, Jianqun</creatorcontrib><creatorcontrib>Zhu, Jinhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bai, Yuwen</au><au>Cao, Kui</au><au>Zhang, Ping</au><au>Ma, Jianqun</au><au>Zhu, Jinhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-12-26</date><risdate>2022</risdate><volume>24</volume><issue>1</issue><spage>375</spage><pages>375-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The family with sequence similarity 72 Member A (FAM72A) is overexpressed in several types of cancer. However, its contributions to tumorigenesis remain largely unknown. Based on The Cancer Genome Atlas (TCGA) database, FAM72A was upregulated across 33 types of cancer. Accordingly, high levels of FAM72A predicted inferior outcomes in half of the cancer types using survival analysis (the Kaplan-Meier curve and univariate Cox regression model). Receiver operating characteristic (ROC) analysis demonstrated that FAM72A showed high accuracy in distinguishing cancerous tissues from normal ones. FAM72A was correlated with immune and stromal scores and immune cell infiltrations in various tumors. Moreover, FAM72A was also associated with tumor mutation burden (TMB), microsatellite instability (MSI), and immune checkpoint genes. Immunophenoscore (IPS) further validated that the FAM72A
tumor showed high immunogenicity and tended to respond to anti-PD1/PDL1/PDL2, anti-CTLA4 treatment, and combined immunotherapies. We also investigated the functional role of FAM72A in lung adenocarcinoma (LUAD). In vitro studies demonstrated that the ectopic expression of FAM72A accelerated the proliferation and migration of NSCLC cells, whereas silencing FAM72A showed the opposite effects on them. In short, FAM72A had prognostic potential and correlated with tumor immunogenicity in various tumors. Functional analysis indicated that FAM72A is an oncogene in LUAD.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>36613817</pmid><doi>10.3390/ijms24010375</doi><orcidid>https://orcid.org/0000-0002-7021-1298</orcidid><orcidid>https://orcid.org/0000-0002-6769-5121</orcidid><orcidid>https://orcid.org/0000-0002-0408-3101</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adenocarcinoma of Lung - immunology Carcinogenesis Carcinoma, Non-Small-Cell Lung - immunology FAM72A Humans LUAD Lung Neoplasms - immunology Membrane Proteins Neoplasm Proteins pan-cancer Prognosis tumor microenvironment |
title | Prognostic and Immunological Implications of FAM72A in Pan-Cancer and Functional Validations |
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