Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-α

•The therapeutic efficacy of the AZT and IFN combination in ATL presumably reflects the inhibition of RT-related functions.•HTLV-1–RT activity from short-term cultured PBMCs may represent a predictive correlate of clinical response to AZT/IFN in ATL patients.

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Bibliographic Details
Published in:Blood advances 2017-05, Vol.1 (12), p.748-752
Main Authors: Macchi, Beatrice, Balestrieri, Emanuela, Frezza, Caterina, Grelli, Sandro, Valletta, Elena, Marçais, Ambroise, Marino-Merlo, Francesca, Turpin, Jocelyn, Bangham, Charles R., Hermine, Olivier, Mastino, Antonio, Bazarbachi, Ali
Format: Article
Language:English
Subjects:
Stimulus Report
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Summary:•The therapeutic efficacy of the AZT and IFN combination in ATL presumably reflects the inhibition of RT-related functions.•HTLV-1–RT activity from short-term cultured PBMCs may represent a predictive correlate of clinical response to AZT/IFN in ATL patients.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2016001370