Cerebral venous sinus thrombosis-associated hemorrhage in vaccine-induced immune thrombotic thrombocytopenia: Catastrophic outcome if delayed diagnosis and treatment

The authors reported the clinical course of a 58-year-old female suffering from cerebral venous sinus thrombosis associated with hemorrhage after the ChAdOx1 nCov-19 vaccination. Emergent decompressive craniectomy was performed, and aggressive blood transfusion was given. Nevertheless, progressive i...

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Bibliographic Details
Published in:Formosan journal of surgery : the official publication of the Surgical Association ... [et al.] 2022-07, Vol.55 (4), p.158-160
Main Authors: Lam, Chee-Tat, Lin, Kuan-Yu, Kao, Ming-Chien, Tsai, Ming-Cheng
Format: Article
Language:English
Subjects:
anti-platelet factor 4 antibodies
Anticoagulants (Medicine)
Blood clot
Blood transfusion
Care and treatment
cerebral venous thrombosis
Complications and side effects
Hemorrhage
Thrombocytopenia
Thrombosis
Vaccination
vaccine-induced immune thrombotic thrombocytopenia
Vaccines
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Summary:The authors reported the clinical course of a 58-year-old female suffering from cerebral venous sinus thrombosis associated with hemorrhage after the ChAdOx1 nCov-19 vaccination. Emergent decompressive craniectomy was performed, and aggressive blood transfusion was given. Nevertheless, progressive intracerebral hemorrhage and thrombocytopenia developed. A delayed diagnosis was made on a rare complication of vaccine-induced immune thrombotic thrombocytopenia (VITT) with a positive result of anti-platelet factor 4 antibodies (PF4 Ab). The patient died 4 days postoperative due to brainstem failure.
ISSN:1682-606X
DOI:10.4103/fjs.fjs_236_21