Effect of remote ischemic preconditioning in the expression of IL-6 and IL-10 in a rat model of liver ischemia-reperfusion injury

PURPOSE: To study the effect of remote ischemic preconditioning (RIPC) in ischemia-reperfusion (I/R) liver injury and in the expression of IL-6 and IL-10 in a rat model. METHODS: Thirty-six male rats were divided in three groups: Sham; I/R injury, a 45 minutes lobar liver ischemia and reperfusion; a...

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Published in:Acta cirúrgica brasileira 2015-07, Vol.30 (7), p.452-460
Main Authors: Guimarães Filho, Marco Antonio Correa, Cortez, Erika, Garcia-Souza, Érica Patrícia, Soares, Vivian de Melo, Moura, Aníbal Sanchez, Carvalho, Laís, Maya, Maria Cristina de Araujo, Pitombo, Marcos Bettini
Format: Article
Language:English
Subjects:
Interleukin-10
Interleukin-6
Ischemic Preconditioning
Rats
Reperfusion Injury
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Summary:PURPOSE: To study the effect of remote ischemic preconditioning (RIPC) in ischemia-reperfusion (I/R) liver injury and in the expression of IL-6 and IL-10 in a rat model. METHODS: Thirty-six male rats were divided in three groups: Sham; I/R injury, a 45 minutes lobar liver ischemia and reperfusion; and RIPC, six cycles of four minutes of ischemia and four minutes of reperfusion on the right hindlimb followed by a 45 minutes lobar liver ischemia and reperfusion. Tissue and blood samples were collected after 1h and 3h of reperfusion for histopathological study, plasma cytokines and alanine aminotransferase (ALT) measurement. RESULTS: The histopathological study demonstrated a significant reduction in liver necrosis in the RIPC group (p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-865020150070000002