Regulation of MAIT cells through host-derived antigens

Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells that function at the interface between innate and acquired immunity. MAIT cells recognize vitamin B2-related metabolites produced by microbes, through semi-invariant T cell receptor (TCR) and contribute to protecti...

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Bibliographic Details
Published in:Frontiers in immunology 2024-06, Vol.15, p.1424987
Main Authors: Ito, Emi, Yamasaki, Sho
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation - immunology
Autoantigens - immunology
bile acids
Histocompatibility Antigens Class I - immunology
Histocompatibility Antigens Class I - metabolism
Humans
Immunology
MAIT cell
Minor Histocompatibility Antigens - immunology
Minor Histocompatibility Antigens - metabolism
MR1 ligand
Mucosal-Associated Invariant T Cells - immunology
Mucosal-Associated Invariant T Cells - metabolism
Receptors, Antigen, T-Cell - immunology
Receptors, Antigen, T-Cell - metabolism
self-antigen
T cell development
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Summary:Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells that function at the interface between innate and acquired immunity. MAIT cells recognize vitamin B2-related metabolites produced by microbes, through semi-invariant T cell receptor (TCR) and contribute to protective immunity. These foreign-derived antigens are presented by a monomorphic antigen presenting molecule, MHC class I-related molecule 1 (MR1). MR1 contains a malleable ligand-binding pocket, allowing for the recognition of compounds with various structures. However, interactions between MR1 and self-derived antigens are not fully understood. Recently, bile acid metabolites were identified as host-derived ligands for MAIT cells. In this review, we will highlight recent findings regarding the recognition of self-antigens by MAIT cells.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1424987