Approach to diagnosing and managing granulomatous-lymphocytic interstitial lung diseaseResearch in context

Granulomatous-lymphocytic interstitial lung disease (GLILD) is a lymphoproliferative and granulomatous pulmonary manifestation of primary immune deficiency diseases, notably common variable immunodeficiency (CVID), and is an important contributor of excess morbidity. As with all forms of ILD, the si...

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Bibliographic Details
Published in:EClinicalMedicine 2024-09, Vol.75, p.102749
Main Authors: Jessica Galant-Swafford, Jason Catanzaro, Rosane Duarte Achcar, Carlyne Cool, Tilman Koelsch, Tami J. Bang, David A. Lynch, Rafeul Alam, Rohit K. Katial, Evans R. Fernández Pérez
Format: Article
Language:English
Subjects:
Common variable immunodeficiency
Diagnosis
Granulomatous-lymphocytic interstitial lung disease
Interstitial lung disease
Multidisciplinary discussion
Treatment
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Summary:Granulomatous-lymphocytic interstitial lung disease (GLILD) is a lymphoproliferative and granulomatous pulmonary manifestation of primary immune deficiency diseases, notably common variable immunodeficiency (CVID), and is an important contributor of excess morbidity. As with all forms of ILD, the significance of utilizing a multidisciplinary team discussion to enhance diagnostic and treatment confidence of GLILD cannot be overstated. In this review, key clinical, radiological, and pathological features are integrated into a diagnostic algorithm to facilitate a consensus diagnosis. As the evidence for diagnosing and managing patients with GLILD is limited, the viewpoints discussed here are not meant to resolve current controversies. Instead, this review aims to provide a practical framework for diagnosing and evaluating suspected cases and emphasizes the importance of a multidisciplinary approach when caring for GLILD patients.
ISSN:2589-5370