A Case of Disseminated Histoplasmosis From California, in the Setting of Secondary Hemophagocytic Lymphohistiocytosis: A Diagnostic Challenge

Histoplasma capsulatum is a geographically specific dimorphic fungus that can cause a spectrum of diseases. While most cases are asymptomatic pulmonary infections, in severe cases, particularly in immunocompromised patients, disseminated disease can occur. Histoplasmosis in California is limited to...

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Bibliographic Details
Published in:JIM - high impact case reports 2023-01, Vol.11, p.23247096231156007-23247096231156007
Main Authors: Govindarajan, Ameish, Sous, Rowis, Venter, Frederick, Torrico, Tyler, Karapetians, Natalie, Heidari, Arash, Cobos, Everardo, Petersen, Greti
Format: Article
Language:English
Subjects:
California
Case Report
Case reports
Fungal infections
Histoplasma
Histoplasmosis - complications
Histoplasmosis - diagnosis
Histoplasmosis - microbiology
Humans
Lymphatic diseases
Lymphohistiocytosis, Hemophagocytic - complications
Lymphohistiocytosis, Hemophagocytic - diagnosis
Medical diagnosis
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Summary:Histoplasma capsulatum is a geographically specific dimorphic fungus that can cause a spectrum of diseases. While most cases are asymptomatic pulmonary infections, in severe cases, particularly in immunocompromised patients, disseminated disease can occur. Histoplasmosis in California is limited to only a few case reports. In this article, we describe a rare case of disseminated histoplasmosis in a non-endemic region presenting with diagnostically challenging symptomatology, including altered mental status, status epilepticus, septic shock, and bilateral adrenal masses.
ISSN:2324-7096
2324-7096
DOI:10.1177/23247096231156007