Features of infllammatory reactions and clinical picture in elderly and young patients with schizophrenia

• Published in: European psychiatry 2021-04, Vol.64 (S1), p.S473-S473
• Main Authors: Androsova, L., Barkhatova, A., Sheshenin, V., Zozulya, S., Otman, I., Pochueva, V., Klyushnik, T.
• Format: Article
• Language: English
• Subjects: Abstract; E-Poster Presentation; inflammatory markers; Older people; Schizophrenia; schizophrenia at young and old age
• ISSN: 0924-9338; 1778-3585
• DOI: 10.1192/j.eurpsy.2021.1262

IntroductionIt is known that the intensity of inflammation weakens with age, and therefore it is of interest to study the clinical features of schizophreniс process in relation to the level of inflammatory markers.ObjectivesTo determine the level of inflammatory markers (the activity of leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI), autoantibodies (aAB) to neurotrophin S100b and myelin basic protein) in plasma in different years old groups of patients with schizophrenia.MethodsTwo groups of patients with schizophrenia were examined: the 1st group - 19 women aged 60 to 78 years; the 2nd group - 24 women aged 19 to 42 years.ResultsAn increase in activity both of LE and α1-PI was found in young patients. This characterizes a balanced inflammatory response. Elderly patients showed a similar increase in the activity of α1-PI, however, LE activity did not exceed the control values. Insufficient LE activity probably characterizes a decrease in the functional activity of neutrophils. The negative correlation was revealed between the activity of LE and TotPsy (PANSS) in the group of elderly patients (r=-0.62, p