U‐Shaped Association Between Serum Uric Acid Levels With Cardiovascular and All‐Cause Mortality in the Elderly: The Role of Malnourishment

Background The link between elevated serum uric acid (SUA) levels and cardiovascular disease (CVD)–related mortality in the elderly population remains inconclusive. Nutritional status influences both SUA and CVD outcomes. Therefore, we investigated whether SUA‐predicted mortality and the effect‐modi...

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Published in:Journal of the American Heart Association 2018-02, Vol.7 (4), p.n/a
Main Authors: Tseng, Wei‐Cheng, Chen, Yung‐Tai, Ou, Shuo‐Ming, Shih, Chia‐Jen, Tarng, Der‐Cherng, Yang, Chih‐Yu, Lin, Yao‐Ping, Chuang, Yi‐Fang, Chen, Liang‐Kung, Wang, Kwua‐Yun, Chen, Yu‐Hsin, Tsai, Ming‐Tsun, Lin, Yi‐Sheng, Hung, Szu‐Chun, Kuo, Ko‐Lin, Hung, Tung‐Po, Hu, Fen‐Hsiang, Chen, Nien‐Jung, Chen, Yu‐Chi, Lin, Chi‐Hung, Tsai, Tung‐Hu, Hsieh, Shie‐Liang, Wei, Yau‐Huei, Hsu, Chih‐Cheng, Liu, Jia‐Sin, Chang, Yu‐Kang, Chiang, Ming‐Han
Format: Article
Language:English
Subjects:
Age Factors
Aged
Biomarkers - blood
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cardiovascular Diseases - physiopathology
Cause of Death
elderly
Female
Geriatric Assessment
Humans
Hyperuricemia - blood
Hyperuricemia - diagnosis
Hyperuricemia - mortality
Longitudinal Studies
Male
malnourishment
Malnutrition - blood
Malnutrition - diagnosis
Malnutrition - mortality
Malnutrition - physiopathology
mortality
Nutrition Assessment
Nutritional Status
Original Research
Prognosis
Risk Assessment
Risk Factors
Taiwan - epidemiology
Time Factors
uric acid
Uric Acid - blood
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Summary:Background The link between elevated serum uric acid (SUA) levels and cardiovascular disease (CVD)–related mortality in the elderly population remains inconclusive. Nutritional status influences both SUA and CVD outcomes. Therefore, we investigated whether SUA‐predicted mortality and the effect‐modifying roles of malnourishment in older people. Methods and Results A longitudinal Taiwanese cohort including 127 771 adults 65 years and older participating in the Taipei City Elderly Health Examination Program from 2001 to 2010 were stratified by 1‐mg/dL increment of SUA. Low SUA (
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.117.007523