Ultra-High Resolution Optical Aberrometry in Patients with Keratoconus: A Cross-Sectional Study

Introduction This study performs optical aberration assessment in patients using a novel ultra-high-resolution device. The objective of this study is to analyze optical aberrations, especially the very high order wavefront (more than 10th order of Zernike coefficients), and compare between keratocon...

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Published in:Ophthalmology and therapy 2023-06, Vol.12 (3), p.1569-1582
Main Authors: Velarde-Rodriguez, Gonzalo, Belda-Para, Carolina, Velasco-Ocaña, Miriam, Trujillo-Sevilla, Juan M., Rodríguez-Martin, Javier, Jiménez-Alfaro, Ignacio, Rodriguez-Ramos, José M., Alejandre-Alba, Nicolas
Format: Article
Language:English
Subjects:
Aberrometry
Cornea
Internal Medicine
Keratoconus
Medicine
Medicine & Public Health
Ophthalmology
Optical aberration
Optics
Original Research
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Summary:Introduction This study performs optical aberration assessment in patients using a novel ultra-high-resolution device. The objective of this study is to analyze optical aberrations, especially the very high order wavefront (more than 10th order of Zernike coefficients), and compare between keratoconus and healthy patients. Methods In this cross-sectional study, we analyzed 43 eyes from 25 healthy patients and 43 eyes from 27 patients with keratoconus using corneal tomography and a very high-resolution (8.55 µm) aberrometer prototype (T-eyede) outfitted with a sensor originally developed for use in the field of astrophysics. Corneal aberration values were assessed using an optical model built with Zemax optical software, while ocular aberrations were assessed using T-eyede. In addition, image-processing analysis was performed of the wavefront phase, creating a high-pass filter map. Results We found lower values for ocular aberrations than corneal aberrations in both groups ( p  
ISSN:2193-8245
2193-6528
DOI:10.1007/s40123-023-00684-2