Non-linear association between serum spermidine and mild cognitive impairment: Results from a cross-sectional and longitudinal study

Although animal studies show that spermidine (SPD) affects cognitive function, the relevant evidence among humans is limited. We aim to examine the association between serum SPD levels and cognitive performance. We conducted a cross-sectional and longitudinal study including a baseline and one follo...

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Bibliographic Details
Published in:Frontiers in aging neuroscience 2022-08, Vol.14, p.924984
Main Authors: Xu, Jiahui, Sun, Zhaoqing, Zhang, Rui, Li, Ruixue, Yu, Zhecong, Zhang, Qianlong, Ma, Yanan, Xing, Fuguo, Zheng, Liqiang
Format: Article
Language:English
Subjects:
Autophagy
cognition
Cognition & reasoning
Cognitive ability
Cohort analysis
Dementia
Dementia disorders
Education
Longitudinal studies
longitudinal study
mild cognitive impairment
Neuroscience
Questionnaires
rural
Rural areas
Spermidine
Surveys
Traumatic brain injury
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Summary:Although animal studies show that spermidine (SPD) affects cognitive function, the relevant evidence among humans is limited. We aim to examine the association between serum SPD levels and cognitive performance. We conducted a cross-sectional and longitudinal study including a baseline and one follow-up survey. The baseline survey was conducted from June 2019 to August 2019, while the follow-up survey was conducted from June 2021 to August 2021. We analyzed 3,774 adult participants aged >35 years, who had no history of dementia. The mean (SD) age of the participants was 57.4 (9.8) years. Relative to the first tertile, the multivariate-adjusted ORs (95% CIs) of mild cognitive impairment (MCI) for the second and third tertile groups were 0.78 (0.65, 0.93) and 0.80 (0.67, 0.96), respectively. Restricted cubic spline models show that there is a non-linear association between SPD and MCI. In line with cross-sectional findings, the longitudinal study showed that a high SPD concentration may indicate a lower risk of MCI [ORs (95% CIs) for the third tertile of 0.62 (0.39, 0.99)]. Our findings suggest that SPD is favorable for cognitive function. Monitoring the SPD levels may help reduce the incidence of MCI, hence decreasing the burden of MCI.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.924984