TRIM Proteins and Their Roles in the Influenza Virus Life Cycle

The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects of cellular physiology. Especially tripartite m...

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Bibliographic Details
Published in:Microorganisms (Basel) 2020-09, Vol.8 (9), p.1424
Main Authors: Lee, Hye-Ra, Lee, Myoung Kyu, Kim, Chan Woo, Kim, Meehyein
Format: Article
Language:English
Subjects:
antiviral immunity
influenza virus
Review
TRIM family
ubiquitination
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Summary:The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects of cellular physiology. Especially tripartite motif (TRIM) proteins, well-known E3 ubiquitin ligases, emerge as having critical roles in several antiviral signaling pathways against varying viral infections. Here we highlight recent advances in the study of antiviral roles of TRIM proteins toward influenza virus infection in terms of the modulation of pathogen recognition receptor (PRR)-mediated innate immune sensing, direct obstruction of influenza viral propagation, and participation in virus-induced autophagy.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms8091424