Electrochemical Sensor Based on Multi-Walled Carbon Nanotubes and N-Doped TiO2 Nanoparticles for Voltametric Simultaneous Determination of Benserazide and Levodopa

An electrochemical sensor for simultaneous determination of Benserazide (BEZ) and levodopa (L-dopa) was successfully developed using a glassy carbon electrode (GCE) modified with multi-walled carbon nanotube and nitrogen-doped titanium dioxide nanoparticles (GCE/MWCNT/N-TiO2). Cyclic voltammetry and...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.27 (23), p.8614
Main Authors: da Silva, Elisangela Pacheco, Araujo, Mayara da Silva, Kunita, Marcos H., Matos, Roberto, Medeiros, Roberta Antigo
Format: Article
Language:English
Subjects:
Analytical chemistry
Benserazide
Carbon
Chemical sensors
Chromatography
Dopamine
Electrochemical analysis
Electrochemistry
Electrodes
Glassy carbon
glassy carbon modified electrode
L-dopa
Levodopa
Liquid chromatography
Morphology
MWCNT
N-doped TiO2
Nanocomposites
Nanomaterials
Nanoparticles
Nanotechnology
Nitrogen
Oxidation
Parkinson's disease
Pharmaceuticals
Solvents
Square waves
square-wave voltammetry
Titanium
Titanium dioxide
Voltammetry
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Summary:An electrochemical sensor for simultaneous determination of Benserazide (BEZ) and levodopa (L-dopa) was successfully developed using a glassy carbon electrode (GCE) modified with multi-walled carbon nanotube and nitrogen-doped titanium dioxide nanoparticles (GCE/MWCNT/N-TiO2). Cyclic voltammetry and square wave voltammetry were employed to investigate the electrochemical behavior of different working electrodes and analytes. In comparison with unmodified GCE, the modified electrode exhibited better electrocatalytic activity towards BEZ and L-dopa and was efficient in providing a satisfactory separation for oxidation peaks, with a potential difference of 140 mV clearly allows the simultaneous determination of these compounds. Under the optimized conditions, linear ranges of 2.0–20.0 and 2.0–70.0 μmol L−1 were obtained for BEZ and L-dopa, respectively, with a limit of detection of 1.6 µmol L−1 for BEZ and 2.0 µmol L−1 for L-dopa. The method was applied in simultaneous determination of the analytes in pharmaceutical samples, and the accuracy was attested by comparison with HPLC-DAD as the reference method, with a relative error lower than 4.0%.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238614