CAR-NK cells for cancer immunotherapy: recent advances and future directions

Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due to their independent cytotoxic capabilities in antitumor immune response. Unlike predominant treatments that target T cell immunity, the limited success of T cell immunotherapy emphasizes the urgenc...

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Bibliographic Details
Published in:Frontiers in immunology 2024, Vol.15, p.1361194-1361194
Main Authors: Li, Tianye, Niu, Mengke, Zhang, Weijiang, Qin, Shuang, Zhou, Jianwei, Yi, Ming
Format: Article
Language:English
Subjects:
adoptive cell transfer
cancer immunotherapy
CAR-NK
Humans
Immunotherapy
Killer Cells, Natural
natural killer cell
Neoplasms
Receptors, Chimeric Antigen - genetics
T-Lymphocytes
the tumor microenvironment
Tumor Microenvironment
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Summary:Natural Killer (NK) cells, intrinsic to the innate immune system, are pivotal in combating cancer due to their independent cytotoxic capabilities in antitumor immune response. Unlike predominant treatments that target T cell immunity, the limited success of T cell immunotherapy emphasizes the urgency for innovative approaches, with a spotlight on harnessing the potential of NK cells. Despite tumors adapting mechanisms to evade NK cell-induced cytotoxicity, there is optimism surrounding Chimeric Antigen Receptor (CAR) NK cells. This comprehensive review delves into the foundational features and recent breakthroughs in comprehending the dynamics of NK cells within the tumor microenvironment. It critically evaluates the potential applications and challenges associated with emerging CAR-NK cell therapeutic strategies, positioning them as promising tools in the evolving landscape of precision medicine. As research progresses, the unique attributes of CAR-NK cells offer a new avenue for therapeutic interventions, paving the way for a more effective and precise approach to cancer treatment.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1361194