Arecae pericarpium extract induces porcine lower-esophageal-sphincter contraction via muscarinic receptors

Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is...

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Bibliographic Details
Published in:BMC complementary and alternative medicine 2021-11, Vol.21 (1), p.275-275, Article 275
Main Authors: Tey, Shu-Leei, Li, Chi-Ying, Lin, Li-Wei, Chang, Li-Ching, Chen, Yea-Ling, Chang, Fang-Rong, Yang, San-Nan, Tsai, Ching-Chung
Format: Article
Language:English
Subjects:
Acetylcholine receptors (muscarinic)
Animals
Areca
Arecae pericarpium
Atropine
Chinese medicine
Chromatography
Contraction
Esophageal sphincter
Esophageal Sphincter, Lower - drug effects
Esophagus
Ethanol
Gastroesophageal reflux
Gastroesophageal Reflux - drug therapy
Herbal medicine
In Vitro Techniques
Intestinal motility
Lower esophageal sphincter
Marine toxins
Medicine, Chinese
Motility
Muscarinic receptor
Muscle contraction
Muscles
Plant Extracts - pharmacology
Receptors
Receptors, Muscarinic - metabolism
Sphincter
Swine
Taiwan
Tetrodotoxin
Traditional Chinese medicine
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Summary:Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few. Arecae pericarpium (A. pericarpium) is a medication in Traditional Chinese Medicine known to promote intestinal motility. We investigated the effect of A. pericarpium extracts on porcine LES motility. In addition, we used tetrodotoxin (TTX) and atropine to study the underlying mechanism of A. pericarpium extracts-induced contractions of LES. The results of this study showed that A. pericarpium extracts and their main active ingredient, arecoline, can induce the contractions of porcine LES sling and clasp muscles in a dose-response manner. TTX did not have an inhibitory effect on the contractions induced by A. pericarpium extracts and arecoline in LES. However, atropine significantly inhibited A. pericarpium extracts- and arecoline-induced contractions of LES. A. pericarpium extracts can induce the contractions of porcine LES in a dose dependent manner, possibly through muscarinic receptors, and hence, may be worth developing as an alternative therapy for GERD.
ISSN:2662-7671
2662-7671
1472-6882
DOI:10.1186/s12906-021-03442-8