Decarboxylation of 2-keto fatty acids by brain

An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid....

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Bibliographic Details
Published in:Journal of lipid research 1966-03, Vol.7 (2), p.270-276
Main Authors: Davies, W E, Hajra, A K, Parmar, S S, Radin, N S, Mead, J F
Format: Article
Language:English
Subjects:
2-ketostearic acid
Adenosine Triphosphate - metabolism
Animals
ascorbic acid
Ascorbic Acid - metabolism
brain
Brain - enzymology
Brain - metabolism
Carboxy-Lyases - metabolism
decarboxylation
Fatty Acids - metabolism
Fumarates - metabolism
fumaric acid
In Vitro Techniques
Iron - metabolism
Keto Acids - metabolism
Magnesium - metabolism
NAD - metabolism
pig
Stearic Acids - metabolism
Subcellular Fractions - metabolism
Swine
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Summary:An enzyme system consisting of washed acetone powder of pig brain, adenosine triphosphate, nicotinamide adenine dinucleotide, magnesium, fumaric acid, and ascorbic acid was found to catalyze the oxidative decarboxylation of 2-ketostearic acid. The products were carbon dioxide and heptadecanoic acid. Washing the enzyme powder with ethylene-diaminetetraacetate and other chelating agents destroyed the activity. Further properties of the enzyme system are described. It is believed that this enzyme system accounts in part for the 1-carbon degradation route for brain fatty acids.
ISSN:0022-2275
DOI:10.1016/S0022-2275(20)39292-0