Inoviridae prophage and bacterial host dynamics during diversification, succession, and Atlantic invasion of Pacific-native Vibrio parahaemolyticus

An understanding of the processes that contribute to the emergence of pathogens from environmental reservoirs is critical as changing climate precipitates pathogen evolution and population expansion. Phylogeographic analysis of hosts combined with the analysis of their phage resolved ambiguities of...

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Bibliographic Details
Published in:mBio 2024-01, Vol.15 (1), p.e0285123-e0285123
Main Authors: Foxall, Randi L, Means, Jillian, Marcinkiewicz, Ashely L, Schillaci, Christopher, DeRosia-Banick, Kristin, Xu, Feng, Hall, Jeffrey A, Jones, Stephen H, Cooper, Vaughn S, Whistler, Cheryl A
Format: Article
Language:English
Subjects:
Bacteria
bacteriophages
Bacteriophages - genetics
Ecosystem
evolutionary biology
Inoviridae
Microbial Ecology
molecular epidemiology
population genetics
Prophages
Research Article
Vibrio
Vibrio parahaemolyticus - genetics
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Summary:An understanding of the processes that contribute to the emergence of pathogens from environmental reservoirs is critical as changing climate precipitates pathogen evolution and population expansion. Phylogeographic analysis of hosts combined with the analysis of their phage resolved ambiguities of diversification dynamics which preceded successful Atlantic invasion by the epidemiologically predominant ST36 lineage. It has been established experimentally that filamentous phage can limit host recombination, but here, we show that phage loss is linked to rapid bacterial host diversification during epidemic spread in natural ecosystems alluding to a potential role for ubiquitous inoviruses in the adaptability of pathogens. This work paves the way for functional analyses to define the contribution of inoviruses in the evolutionary dynamics of environmentally transmitted pathogens.
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.02851-23