Glycyrrhetic Acid Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Vivo

Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely used in clinical health care. Glycyrrhetic acid (GA) is an aglycone saponin extracted from GR that has anti-inflammatory, anti-cancer, and anti-viral effects. However, the anti-inflammatory effects of GA in colitis have not...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2016-04, Vol.21 (4), p.523-523
Main Authors: Jeon, Yong-Deok, Kang, Sa-Haeng, Bang, Keuk-Soo, Chang, Young-Nam, Lee, Jong-Hyun, Jin, Jong-Sik
Format: Article
Language:English
Subjects:
Animals
anti-inflammation
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - pharmacology
Colitis, Ulcerative - chemically induced
Colitis, Ulcerative - drug therapy
Colitis, Ulcerative - metabolism
Colon - drug effects
Dextran Sulfate - adverse effects
dextran sulfate sodium
Disease Models, Animal
Gene Expression Regulation
glycyrrhetic acid
Glycyrrhetinic Acid - administration & dosage
Glycyrrhetinic Acid - pharmacology
Glycyrrhiza - chemistry
Interleukin-1beta - metabolism
Interleukin-6 - metabolism
Male
Mice
Plant Extracts - chemistry
Tumor Necrosis Factor-alpha - metabolism
ulcerative colitis
Weight Loss - drug effects
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Summary:Glycyrrhizae Radix (GR) is a Korean traditional herb medicine that is widely used in clinical health care. Glycyrrhetic acid (GA) is an aglycone saponin extracted from GR that has anti-inflammatory, anti-cancer, and anti-viral effects. However, the anti-inflammatory effects of GA in colitis have not been reported. This study investigated the role of GA on ulcerative colitis in a dextran sulfate sodium (DSS)-induced mouse colitis model. DSS-treated mice displayed weight loss and shortened colon length compared with control mice. Mice administered GA showed less weight loss and longer colon length than the DSS-treated group. Interleukin (IL)-6, IL-1β, and tumor necrosis factor-alpha were decreased by GA treatment. GA treatment also reduced DSS-induced microscopic damage to colon tissue. GA regulates the phosphorylation of transcription factors including nuclear factor-kappa B (NF-κB) and IκB alpha, and regulates the expression of cycloxygenase-2 and prostaglandin E₂. GA thus showed beneficial effects in a mouse model of colitis, implicating GA might be a useful herb-derived medicine in the treatment of ulcerative colitis.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules21040523