A Reversible Cause of Skin Hyperpigmentation and Postural Hypotension

Vitamin B12 deficiency results in neuropsychiatric, hematologic, gynecologic, cardiovascular, and cutaneous manifestations. It is seen most commonly in the elderly, malabsorption diseases  (>60% of all cases), vegans, and vegetarians. Manifestations of pernicious anemia may be similar to Addison...

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Bibliographic Details
Published in:Case reports in hematology 2013-01, Vol.2013 (2013), p.1-5
Main Authors: Cherqaoui, Rabia, Husain, Mehreen, Madduri, Sujay, Okolie, Pamela, Nunlee-Bland, Gail, Williams, James
Format: Article
Language:English
Subjects:
Blood pressure
Case Report
Consciousness
Fatigue
Hair
Heart
Heart rate
Hypertension
Medical treatment
Skin
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Summary:Vitamin B12 deficiency results in neuropsychiatric, hematologic, gynecologic, cardiovascular, and cutaneous manifestations. It is seen most commonly in the elderly, malabsorption diseases  (>60% of all cases), vegans, and vegetarians. Manifestations of pernicious anemia may be similar to Addison disease and may lead to a misdiagnosis. Herein, we report two cases of vitamin B12 deficiency in which clinical features shared many similarities with Addison disease. Both patients presented with progressive darkening of hands and postural hypotension that reversed with replenishment of vitamin B12. Vitamin B12 deficiency should be considered in patients presenting with skin lesions especially with other coexisting autoimmune diseases.
ISSN:2090-6560
2090-6579
DOI:10.1155/2013/680459