Interplay between Inflammation and Pathological Bone Resorption: Insights into Recent Mechanisms and Pathways in Related Diseases for Future Perspectives

Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active organ that undergoes continuous remodeling processes t...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-02, Vol.23 (3), p.1786
Main Authors: Terkawi, M Alaa, Matsumae, Gen, Shimizu, Tomohiro, Takahashi, Daisuke, Kadoya, Ken, Iwasaki, Norimasa
Format: Article
Language:English
Subjects:
Adapter proteins
Biomedical materials
bone
Bone diseases
bone osteolytic diseases
Bone remodeling
Bone resorption
Bone Resorption - physiopathology
Bone turnover
Chemokines
Cytokines
Disease
Growth factors
Homeostasis
Humans
Immune system
Inflammation
Joint diseases
Kinases
Ligands
Microenvironments
Minerals
Molecular modelling
Muscles
Organs
Osteoclasts - physiology
Osteolysis
Osteoporosis
pathological bone resorption
Physiology
Public health
remodeling
Review
Rheumatoid arthritis
Signal transduction
Transcription factors
Tumor necrosis factor-TNF
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Summary:Bone is a mineralized and elastic connective tissue that provides fundamental functions in the human body, including mechanical support to the muscles and joints, protection of vital organs and storage of minerals. Bone is a metabolically active organ that undergoes continuous remodeling processes to maintain its architecture, shape, and function throughout life. One of the most important medical discoveries of recent decades has been that the immune system is involved in bone remodeling. Indeed, chronic inflammation has been recognized as the most significant factor influencing bone homeostasis, causing a shift in the bone remodeling process toward pathological bone resorption. Bone osteolytic diseases typified by excessive bone resorption account for one of the greatest causes of disability worldwide, with significant economic and public health burdens. From this perspective, we discuss the recent findings and discoveries highlighting the cellular and molecular mechanisms that regulate this process in the bone microenvironment, in addition to the current therapeutic strategies for the treatment of osteolytic bone diseases.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23031786