Pediatric M5 acute myeloid leukemia with MLL-SEPT6 fusion and a favorable outcome

Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with...

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Bibliographic Details
Published in:Leukemia research reports 2021-01, Vol.16, p.100277, Article 100277
Main Authors: Chebly, Alain, Djambas Khayat, Claudia, Yammine, Tony, Korban, Rima, Semaan, Warde, Bou Zeid, Jessica, Farra, Chantal
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
AML
MLL
SEPT6
Septin
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Summary:Acute myeloid leukemia (AML) patients with MLL-SEPT6 fusion represent a small subset of AML. The uncommon MLL-SEPT6 rearrangement results from t(X;11) or other variants like ins(X;11), and it is usually associated with complex cytogenetic abnormalities. We herein report a case of AML-M5-infant with ins(X;11)(q24;q23q13) and MLL-SEPT6. The one-year-old boy presented with leukocytosis, anemia and thrombocytopenia. He had a favorable response to chemotherapy according to ELAM02protocol and is currently in complete remission. We here, highlight the occurrence of MLL-SEPT6 as the sole abnormality in a pediatric-AML-M5 case, discuss the prognostic implication of this genetic variant, while reviewing previously reported AML-MLL-SEPT6 cases.
ISSN:2213-0489
2213-0489
DOI:10.1016/j.lrr.2021.100277