Derivation of the human embryonic stem cell line RCM1

The human embryonic stem cell line RCM-1 was derived from a failed to fertilise egg undergoing parthenogenetic stimulation. The cell line shows normal pluripotency marker expression and differentiation to three germ layers in vitro and in vivo. It has a normal 46XX female karyotype and microsatellit...

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Bibliographic Details
Published in:Stem cell research 2016-03, Vol.16 (2), p.476-480
Main Authors: De Sousa, P.A., Tye, B.J., Sneddon, S., Bruce, K., Dand, P., Russell, G., Collins, D.M., Greenshields, A., McDonald, K., Bradburn, H., Gardner, J., Downie, J.M., Courtney, A., Brison, D.R.
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Cells, Cultured
Cellular Reprogramming
Comparative Genomic Hybridization
Embryoid Bodies - cytology
Female
Flow Cytometry
Histocompatibility Testing
Human Embryonic Stem Cells - cytology
Human Embryonic Stem Cells - metabolism
Human Embryonic Stem Cells - transplantation
Humans
Karyotype
Mice
Mice, SCID
Microsatellite Repeats - genetics
Microscopy, Fluorescence
Ovum - cytology
Teratoma - metabolism
Teratoma - pathology
Transcription Factors - genetics
Transcription Factors - metabolism
Transplantation, Heterologous
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Summary:The human embryonic stem cell line RCM-1 was derived from a failed to fertilise egg undergoing parthenogenetic stimulation. The cell line shows normal pluripotency marker expression and differentiation to three germ layers in vitro and in vivo. It has a normal 46XX female karyotype and microsatellite PCR identity, HLA and blood group typing data is available.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2015.12.020