The role of targeted therapy in the management of patients with AML

Drug therapy for acute myeloid leukemia (AML) is finally undergoing major changes in 2017. This is due to the US Food and Drug Administration's approval of several new, targeted agents (midostaurin, enasidenib, and gemtuzumab ozogamicin). Paired with the recent approval of a novel liposomal for...

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Bibliographic Details
Published in:Blood advances 2017-11, Vol.1 (24), p.2281-2294
Main Author: Perl, Alexander E.
Format: Article
Language:English
Subjects:
Review
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Summary:Drug therapy for acute myeloid leukemia (AML) is finally undergoing major changes in 2017. This is due to the US Food and Drug Administration's approval of several new, targeted agents (midostaurin, enasidenib, and gemtuzumab ozogamicin). Paired with the recent approval of a novel liposomal formulation of daunorubicin/cytarabine (CPX-351/Vyxeos), the standard of care is changing rapidly in AML for subgroups. This review will focus on currently approved agents and promising novel agents in development and will highlight controversial areas in targeted treatment.
ISSN:2473-9529
2473-9537
DOI:10.1182/bloodadvances.2017009829