P-6 CORRELATION BETWEEN CONNECTIVE TISSUE GROWTH FACTOR (CTGF) AND FIBROSIS DEGREE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS (PBC)

• Published in: Annals of hepatology 2024-12, Vol.29, p.101620
• Main Authors: Sánchez, Cristian Yamín Sánchez, Rivera, Diego Fernando Abendaño, De Guevara, Viridiana López Ladrón, Castro, María Argentina Díaz, de da Tijera, Fátima Higuera, Arriaga, Carolina Guzmán, Vargas, Ángel Daniel Santana, Hernández, José Luis Pérez
• Format: Article
• Language: English
• ISSN: 1665-2681
• DOI: 10.1016/j.aohep.2024.101620

No Connective Tissue Growth Factor (CTGF) is a multifunctional protein recognized as an important mediator in fibrogenic pathways in liver diseases. Primary Biliary Cholangitis (PBC) is a chronic autoimmune disease that affects the bile ducts. It is characterized by inflammation and progressive fibrosis of the bile ducts, which can lead to stenosis, cholestasis, and long-term liver damage. The objective of this study is to establish the correlation between serum levels of Connective Tissue Growth Factor (CTGF), measured using Enzyme-Linked Immunosorbent Assay (ELISA), and the degree of hepatic fibrosis assessed by transient elastography in patients with cholestasis diagnosed with Primary Biliary Cholangitis (PBC). Prospective, analytical, experimental study. Three groups were recruited: the first group comprised patients with cholestasis, the second group comprised patients with cirrhosis due to Hepatitis C Virus (HCV), and the third group comprised healthy subjects. Anthropometric and biochemical data were collected. A blood sample was collected to quantify serum levels of CTGF using ELISA. The degree of fibrosis was determined by transient elastography. Statistical analysis: Data are presented as Mean±SD or Median (IQR 25-75). They were analyzed by one-way ANOVA with Tukey's post-hoc test or Kruskal-Wallis with Dunn's post-hoc test. The following parameters were calculated: Sensitivity (S), Specificity (E), Positive Predictive Values (PPV), Negative Predictive Values (NPV), and the area under the ROC curve (AUROC). A p-value