New challenges for microRNAs in acute pancreatitis: progress and treatment

Acute pancreatitis (AP) is a common clinical abdominal emergency, with a high and increasing incidence each year. Severe AP can easily cause systemic inflammatory response syndrome, multiple organ dysfunction and other complications, leading to higher hospitalization rates and mortality. Currently,...

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Bibliographic Details
Published in:Journal of translational medicine 2022-05, Vol.20 (1), p.192-192, Article 192
Main Authors: Zhou, Wence, Dong, Shi, Chen, Zhou, Li, Xin, Jiang, Wenkai
Format: Article
Language:English
Subjects:
Acute Disease
Acute pancreatitis
Apoptosis
Bioinformatics
Cancer therapies
Cytokines
Development and progression
Experiments
Gene expression
Genetic aspects
Genomes
Growth factors
Health aspects
Humans
Inflammation
Inflammatory diseases
MicroRNA
MicroRNAs
MicroRNAs - genetics
miRNA
Molecular markers
Mortality
Pancreatic cancer
Pancreatitis
Pancreatitis - genetics
Pancreatitis - therapy
Pathogenic mechanism
Physiological aspects
Regulation
Review
Systemic inflammatory response syndrome
Transcriptomics
Treatment
Tumor necrosis factor-TNF
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Summary:Acute pancreatitis (AP) is a common clinical abdominal emergency, with a high and increasing incidence each year. Severe AP can easily cause systemic inflammatory response syndrome, multiple organ dysfunction and other complications, leading to higher hospitalization rates and mortality. Currently, there is no specific treatment for AP. Thus, we still need to understand the exact AP pathogenesis to effectively cure AP. With the rise of transcriptomics, RNA molecules, such as microRNAs (miRNAs) transcribed from nonprotein-coding regions of biological genomes, have been found to be of great significance in the regulation of gene expression and to be involved in the occurrence and development of many diseases. Increasing evidence has shown that miRNAs, as regulatory RNAs, can regulate pancreatic acinar necrosis and apoptosis and local and systemic inflammation and play an important role in the development and thus potentially the diagnosis and treatment of AP. Therefore, here, the current research on the relationship between miRNAs and AP is reviewed.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-022-03338-2