Maltodextrin-Nanoparticles as a Delivery System for Nasal Vaccines: A Review Article

Nanoparticles are increasingly being studied as antigen delivery systems for immunization with nasal vaccines. The addition of adjuvants is still generally required in many nanoparticle formulations, which can induce potential side effects owing to mucosal reactogenicity. In contrast, maltodextrin n...

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Bibliographic Details
Published in:Pharmaceutics 2024-02, Vol.16 (2), p.247
Main Authors: Fasquelle, François, Scuotto, Angelo, Howsam, Michael, Betbeder, Didier
Format: Article
Language:English
Subjects:
antibacterial vaccines
Antigens
antiparasitic vaccines
antiviral vaccines
Bad debts
Dextrins
Health aspects
Immune response
Life Sciences
Lipids
maltodextrin
Microscopy
Nanoparticles
nasal vaccine
Parasitic diseases
Proteins
Review
Vaccines
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Summary:Nanoparticles are increasingly being studied as antigen delivery systems for immunization with nasal vaccines. The addition of adjuvants is still generally required in many nanoparticle formulations, which can induce potential side effects owing to mucosal reactogenicity. In contrast, maltodextrin nanoparticles do not require additional immunomodulators, and have been shown to be efficient vaccine delivery systems. In this review, the development of maltodextrin nanoparticles is presented, specifically their physico-chemical properties, their ability to load antigens and deliver them into airway mucosal cells, and the extent to which they trigger protective immune responses against bacterial, viral, and parasitic infections. We demonstrate that the addition of lipids to maltodextrin nanoparticles increases their potency as a vaccine delivery system for nasal administration.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics16020247