Serum albumin level as an indicator of response to Hepatitis B vaccination in dialysis patients: A systematic review and meta-analysis

Hepatitis B (HB) vaccination is a recommended procedure in all dialysis patients, but its efficacy has not been perfect. In the current study, we aimed to conduct a comprehensive review of the literature to find and pool data of the randomized trials evaluating the impact of serum albumin levels on...

Full description

Saved in:
Bibliographic Details
Published in:Caspian journal of internal medicine 2017-01, Vol.8 (4), p.250-257
Main Authors: Ghamar-Chehreh, Mohammad Ebrahim, Agah, Shahram, Khedmat, Hossein, Aghaei, Aghdas, Alavian, Seyed-Moayed
Format: Article
Language:English
Subjects:
dialysis patients
efficacy
ESRD
Hepatitis B virus
immunogenicity
Review
serum albumin
vaccination
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hepatitis B (HB) vaccination is a recommended procedure in all dialysis patients, but its efficacy has not been perfect. In the current study, we aimed to conduct a comprehensive review of the literature to find and pool data of the randomized trials evaluating the impact of serum albumin levels on the immunogenicity of HB vaccination in dialysis patients. Literature searches were conducted by the Medline and Google Scholar. The key words used included 'Hepatitis B', 'Vaccine', 'Dialysis', 'Hemodialysis', and 'Albumin'. Data of serum albumin levels regarding seroresponse to HB vaccine in clinical trials have been achieved and analyzed. Finally, data from 17 clinical trials have been pooled and analyzed. One thousand six hundred eighty-two dialysis patients (1212 seroconverted) were included in the meta-analysis. Analysis of response to HB vaccination in our dialysis population showed a significant relationship to their serum albumin levels (p
ISSN:2008-6164
2008-6172
DOI:10.22088/cjim.8.4.250