Recent advances on the synthesis of natural pyrrolizidine alkaloids: alexine, and its stereoisomers

Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala . The biological properties such as glycosidase i...

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Bibliographic Details
Published in:Natural products and bioprospecting 2022-12, Vol.12 (1), p.3-15, Article 3
Main Authors: Mohammadi Ziarani, Ghodsi, Jamasbi, Negar, Mohajer, Fatemeh
Format: Article
Language:English
Subjects:
Acids
Alcohol
Alexa leiopetala
Alexine
Alkaloids
Biological properties
Biomedical and Life Sciences
Bioorganic Chemistry
Chloride
Food Science
Glycosidases
HIV
Human immunodeficiency virus
Life Sciences
Medicinal Chemistry
Natural products
Pharmacology/Toxicology
Plant Biochemistry
Plant Sciences
Polyhydroxylated pyrrolizidine alkaloids
Pyrrolizidine alkaloids
Review
Stereoisomerism
Stereoisomers
Synthesis
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Summary:Natural products have attracted the interest of the scientific community due to their importance and application. Alexine is a naturally polyhydroxylated pyrrolizidine alkaloid that is broadly found in plant sources and isolated from Alexa leiopetala . The biological properties such as glycosidase inhibitors, anti-virus, and anti-HIV activities, makes it interesting target for synthetical studies. This review reports different approaches and methodologies to the synthesis of alexine, and its stereoisomers as the target compounds in numerous studies. Graphical Abstract
ISSN:2192-2195
2192-2209
DOI:10.1007/s13659-022-00324-5