MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products

• Published in: Scientific reports 2023-12, Vol.13 (1), p.21304-21304, Article 21304
• Main Authors: Pezhhanfar, Sakha, Farajzadeh, Mir Ali, Kheirkhah Ghaleh, Mahdi, Hosseini-Yazdi, Seyed Abolfazl, Afshar Mogaddam, Mohammad Reza
• Format: Article
• Language: English
• Subjects: 639/638; 704/172; Absorbents; Absorption; Acetic anhydride; Centrifugation; Chemistry; Chromatography, Gas - methods; Deodorants; Ethylene dibromide; High temperature; Humanities and Social Sciences; Ionization; Ligands; Methanol; multidisciplinary; Parabens - analysis; Science; Science (multidisciplinary); Sodium; Sodium carbonate; Sodium Chloride; Solid Phase Extraction - methods; Solvents
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-48880-1

This study was the first-ever attempt to apply MIL-68 (Ga) in developing an analytical method. The method extracts and preconcentrates some parabens from mouthwash and hydrating gel samples. The variable extraction parameters were optimized, and the figures of merit were documented. Avogadro software was used besides discussing intermolecular interactions to clarify the absorption process. ComplexGAPI software was also exploited to assess the greenness of the method. After the derivatization of the parabens using acetic anhydride in the presence of sodium carbonate, sodium chloride was added to the solution and vortexed to dissolve. A few milligrams of MIL-68 (Ga) were added into the solution and vortexed. Centrifugation separated the analyte-loaded absorbent, which was treated with mL volume of methanol through vortexing for desorption aim. A few microliters of 1,2-dibromoethane were merged with the methanolic phase and injected into a sodium chloride solution. One microliter of the extracted phase was injected into a gas chromatograph equipped with a flame ionization detector. High enrichment factors (200–330), reasonable extraction recoveries (40–66%), wide linear ranges (265–30,000 µg L −1 ), and appreciable coefficients of determination (0.996–0.999) were documented. The applicability of dispersive solid phase extraction for extracting polar analytes, imposing no additional step for performing derivatization, the capability of MIL-68 (Ga) for the absorption of both derivatized and non-derivatized parabens, the use of only 10 mg absorbent, and one-pot synthesis besides no high temperature or long reaction time in the sorbent provision are the highlights of the method.