The advanced lung cancer inflammation index is a novel independent prognosticator in colorectal cancer patients after curative resection

Background The advanced lung cancer inflammation index (ALI), which comprehensively evaluates the patient body composition and inflammation/nutritional status, is reportedly associated with the patient outcome in lung cancer. However, the clinical significance in colorectal cancer (CRC) patients aft...

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Bibliographic Details
Published in:Annals of gastroenterological surgery 2022-01, Vol.6 (1), p.83-91
Main Authors: Horino, Taichi, Tokunaga, Ryuma, Miyamoto, Yuji, Hiyoshi, Yukiharu, Akiyama, Takahiko, Daitoku, Nobuya, Sakamoto, Yuki, Yoshida, Naoya, Baba, Hideo
Format: Article
Language:English
Subjects:
advanced lung cancer inflammation index
Antigens
Body mass index
Cancer therapies
Classification
Clinical outcomes
Colorectal cancer
Inflammation
Lung cancer
Lymphatic system
Lymphocytes
Medical prognosis
Metastasis
Mortality
Neutrophils
Original
Patients
postoperative complication
recurrence
Survival analysis
systemic inflammation
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Summary:Background The advanced lung cancer inflammation index (ALI), which comprehensively evaluates the patient body composition and inflammation/nutritional status, is reportedly associated with the patient outcome in lung cancer. However, the clinical significance in colorectal cancer (CRC) patients after curative resection remains unclear. Methods A total of 813 CRC patients after curative resection between April 2005 and June 2019 in a single institution were retrospectively enrolled. The association of the preoperative ALI (calculated as follows: body mass index × albumin value/neutrophil‐to‐lymphocyte ratio) with clinicopathological factors, postoperative complications, and survival was analyzed. Results A low ALI was significantly associated with male gender, older age, a higher depth of tumor invasion, progressed TNM stage, and preoperative carcinoembryonic antigen (CEA) positivity. Both postoperative complications and severe complications occurred more frequently in the ALI‐low group than in the ALI‐high group (P 
ISSN:2475-0328
2475-0328
DOI:10.1002/ags3.12499