TLR4-IN-C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis

Acute kidney injury (AKI) is a major component of isoproterenol (ISO) induced cardiorenal syndrome. In this study, we investigated the effect of TLR4-IN-C34 as a toll-like receptor (TLR)-4 inhibitor on ameliorating ISO-induced AKI and the possible molecular underlying pathways. The study included 4...

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Bibliographic Details
Published in:Iranian journal of basic medical sciences 2022-11, Vol.25 (11), p.1334-1340
Main Authors: Abdelsalam, Hadeer M, Helal, Manar G, Abu-Elsaad, Nashwa M
Format: Article
Language:English
Subjects:
Apoptosis
Creatinine
Cytokines
Design
Heart attacks
isoproterenol
Kidneys
Kinases
mapk
myd88
nf-kappa b
Pharmacology
Pharmacy
toll-like receptor
Toxicology
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Summary:Acute kidney injury (AKI) is a major component of isoproterenol (ISO) induced cardiorenal syndrome. In this study, we investigated the effect of TLR4-IN-C34 as a toll-like receptor (TLR)-4 inhibitor on ameliorating ISO-induced AKI and the possible molecular underlying pathways. The study included 4 groups: control group, ISO group (rats received 100 mg/kg ISO in 2 doses 24 hr apart, SC), ISO+C341 and ISO+C343 groups (rats received 1 or 3 mg/kg TLR4-IN-C34 respectively twice one hour before each ISO injection, IP). Obtained results showed that TLR4-IN-C34 injection prior to ISO decreased serum creatinine level
ISSN:2008-3866
2008-3874
DOI:10.22038/ijbms.2022.67168.14727