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Prevention of Bacterial Biofilm Formation on Soft Contact Lenses Using Natural Compounds
Purpose In eye care field, contact lenses (CL) have a great impact on improving vision, but their use can be limited by ocular infection. CL- associated infections can be reduced by good attention to CL storage case practice. CL-care solutions should be able to control microbial growth on CL. The ai...
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Published in: | Journal of ophthalmic inflammation and infection 2017-04, Vol.7 (1), p.11-11, Article 11 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Purpose
In eye care field, contact lenses (CL) have a great impact on improving vision, but their use can be limited by ocular infection. CL- associated infections can be reduced by good attention to CL storage case practice. CL-care solutions should be able to control microbial growth on CL.
The aim of the study was to evaluate and compare the efficacy of CL-care solutions (found in Egyptian market) with some natural compounds in removal and inhibition of bacterial biofilm formed on soft CL.
Clinical isolates were recovered from patients having conjunctivitis from Benha University Hospital and identified microbiologically. Quantification of biofilm was done using microtiter plate assay. Three multipurpose CL-care solutions were examined for their ability to remove and inhibit biofilm. Also four natural extracts having antibacterial activity and are safe on eye were tested for their anti-biofilm activity.
Results
The major bacterial isolates from eye infections were
Pseudomonas aeruginosa
(36%) and
Staphylococcus spp.
(37.8%). Only 33.3% of isolates showed ability to produce weak to moderate biofilm. The tested multi-purpose CL-care solutions showed moderate ability to remove preformed biofilm. Among the tested natural compounds,
Calendula officinalis
and
Buddleja salviifolia
extracts showed an excellent efficacy in inhibition of biofilm and also removal of preformed biofilm.
Conclusion
This study demonstrated that isolates from infected eye and CL-cases showed weak to moderate biofilm formation.
Calendula officinalis
and
Buddleja salviifolia
extracts showed excellent effect on inhibition and removal of biofilm, these extracts could be added into CL-care solutions which could markedly reduce eye-infections during CL-wear. |
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ISSN: | 1869-5760 1869-5760 |
DOI: | 10.1186/s12348-017-0129-0 |