Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis

Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymphoid tissues. High expression of TLS in tumor tissues is generally associated with better p...

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Bibliographic Details
Published in:BMC cancer 2024-07, Vol.24 (1), p.815-10, Article 815
Main Authors: Ma, Luyuan, Li, Rongyang, Liu, Xiaomeng, Yu, Wenhao, Tang, Zhanpeng, Shen, Yi, Tian, Hui
Format: Article
Language:English
Subjects:
Analysis
B cells
Biomarkers
Biomarkers, Tumor - metabolism
Carcinoma, Non-Small-Cell Lung - immunology
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Care and treatment
Citations
Disease-Free Survival
Humans
Immunotherapy
Leukocytes (neutrophilic)
Lung cancer
Lung cancer, Non-small cell
Lung cancer, Small cell
Lung Neoplasms - immunology
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lymphocytes
Lymphoid tissue
Medical prognosis
Medical research
Medicine, Experimental
Meta-analysis
Metastases
Metastasis
Multivariate analysis
Non-small cell lung cancer
Non-small cell lung carcinoma
Patients
Physiological aspects
Prognosis
Sensitivity analysis
Small cell lung carcinoma
Software
Structure
Surgery
Systematic Review
Tertiary lymphoid structures
Tertiary Lymphoid Structures - immunology
Tertiary Lymphoid Structures - pathology
Tumors
Citations: Items that this one cites
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Description
Summary:Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymphoid tissues. High expression of TLS in tumor tissues is generally associated with better prognosis. This research aimed to investigate the prognostic and clinicopathological significance of TLS in patients with NSCLC. A comprehensive literature search was conducted based on Pubmed, EMBASE, and Cochrane Library databases to identify eligible studies published up to December 8, 2023. The prognostic significance and clinicopathological value of TLS in NSCLC were evaluated by calculating the combined hazard ratios (HRs) and odds ratios (ORs) and their 95% confidence intervals (CIs). Following that, additional analyses, including subgroup analysis and sensitivity analysis, were conducted. This meta-analysis evaluated the prognostic and clinicopathological significance of TLS in 10 studies involving 1,451 patients with NSCLC. The results revealed that the high levels of TLS were strongly associated with better overall survival (OS) (HR = 0.48, 95% CI: 0.35-0.66, p 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-12587-x