Analysis of Long Non-Coding RNA (lncRNA) UCA1, MALAT1, TC0101441, and H19 Expression in Endometriosis

Endometriosis is a disease of complex etiology. Hormonal, immunological, and environmental factors are involved in its formation. In recent years, special attention has been paid to genetic mechanisms that can have a significant impact on the increased incidence of endometriosis. The study aimed to...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (19), p.11583
Main Authors: Szaflik, Tomasz, Romanowicz, Hanna, Szyłło, Krzysztof, Kołaciński, Radosław, Michalska, Magdalena M., Samulak, Dariusz, Smolarz, Beata
Format: Article
Language:English
Subjects:
Biomarkers
Cell growth
Disease
Endometriosis
Endometrium
Estrogens
Etiology
Gene expression
Genes
Genetic screening
H19
H19 gene
Hormone replacement therapy
Immunology
Infertility
lncRNA
MALAT1
MicroRNAs
Miscarriage
Non-coding RNA
Ovarian cancer
Paraffins
Pathogenesis
Statistical analysis
TC0101441
UCA1
Womens health
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Summary:Endometriosis is a disease of complex etiology. Hormonal, immunological, and environmental factors are involved in its formation. In recent years, special attention has been paid to genetic mechanisms that can have a significant impact on the increased incidence of endometriosis. The study aimed to analyze the expression of four long non-coding RNA (lncRNA) genes, UCA1, MALAT1, TC0101441, and H19, in the context of the risk of developing endometriosis. The material for genetic testing for the expression of lncRNA genes were tissue slices embedded in paraffin blocks from patients with endometriosis (n = 100) and the control group (n = 100). Gene expression was determined by the RT-PCR technique. The expression of the H19 gene in endometriosis patients was statistically significantly lower than in the control group. A statistically significant association was found between H19 gene expression in relation to The Revised American Society for Reproductive Medicine classification of endometriosis (rASRM) in the group of patients with endometriosis. Research suggests that H19 expression plays an important role in the pathogenesis of endometriosis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911583