Metastatic gallbladder adenocarcinoma with signet-ring cells: A case report

Signet-ring cell carcinoma is a rare and aggressive variant of mucinous adenocarcinoma. Only a few cases of gallbladder adenocarcinoma with signet-ring cells have been reported and because of this there is a lack of knowledge about the behavior and biology of this pathology. We present the case of a...

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Bibliographic Details
Published in:Journal of medical case reports 2011-09, Vol.5 (1), p.458-458, Article 458
Main Authors: Bazan, Fernando, Sanchez, Juan, Aguilar, Guadalupe, Radosevic, Aleksandar, Busto, Marcos, Zuccarino, Flavio, Pijuan, Lara, Risueño, Noelia
Format: Article
Language:English
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Case Report
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Summary:Signet-ring cell carcinoma is a rare and aggressive variant of mucinous adenocarcinoma. Only a few cases of gallbladder adenocarcinoma with signet-ring cells have been reported and because of this there is a lack of knowledge about the behavior and biology of this pathology. We present the case of a 63-year-old Arab man with gallbladder signet-ring cell adenocarcinoma. He had an elective cholecystectomy and refused chemotherapy. Two months later, a small hepatic metastatic nodule was found, and nine months later he presented with multiple metastases in the liver, lymphatic nodes, both pleuras, peritoneum and subcutaneous tissue. The proliferation of signet-ring cells in a gallbladder adenocarcinoma worsens the prognosis of an already adverse neoplasm. New lines of treatment in chemotherapy, such as cisplatin, or new biological therapy, such as monoclonal antibody c-myc oncogene, should be encouraged to improve the survival and life quality of these oncologic patients.
ISSN:1752-1947
1752-1947
DOI:10.1186/1752-1947-5-458