A Novel Quality-Control Procedure to Improve the Accuracy of Rare Variant Calling in SNP Arrays

Single-nucleotide polymorphism (SNP) arrays are an ideal technology for genotyping genetic variants in mass screening. However, using SNP arrays to detect rare variants [with a minor allele frequency (MAF) of

Saved in:
Bibliographic Details
Published in:Frontiers in genetics 2021-10, Vol.12, p.736390-736390
Main Authors: Sun, Ting-Hsuan, Shao, Yu-Hsuan Joni, Mao, Chien-Lin, Hung, Miao-Neng, Lo, Yi-Yun, Ko, Tai-Ming, Hsiao, Tzu-Hung
Format: Article
Language:English
Subjects:
disease screening
Genetics
genotyping
quality-control
rare variant
SNP array
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Single-nucleotide polymorphism (SNP) arrays are an ideal technology for genotyping genetic variants in mass screening. However, using SNP arrays to detect rare variants [with a minor allele frequency (MAF) of
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2021.736390