Pathoimmunological analyses of fatal E11 infection in premature infants

E11 causes acute fulminant hepatitis in newborns. We investigated the pathological changes of different tissues from premature male twins who died due to E11 infection. The E11 expression level was higher in the liver than in other tissues. IP10 was upregulated in liver tissue in the patient group,...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2024-07, Vol.14, p.1391824
Main Authors: Luo, Wei, Wang, Lixia, Chen, Zhengrong, Liu, Ming, Zhao, Yixue, Wu, Yucan, Huang, Bing, Wang, Ping
Format: Article
Language:English
Subjects:
acute fulminant hepatitis
Cellular and Infection Microbiology
Chemokine CXCL10
E11
Fatal Outcome
Humans
IFNα
Infant, Newborn
Infant, Premature
Interferon-alpha
IP10
Liver - pathology
Male
premature male twins
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Summary:E11 causes acute fulminant hepatitis in newborns. We investigated the pathological changes of different tissues from premature male twins who died due to E11 infection. The E11 expression level was higher in the liver than in other tissues. IP10 was upregulated in liver tissue in the patient group, and might be regulated by IFNAR and IRF7, whereas IFNα was regulated by IFNAR or IRF5.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2024.1391824