Integrative analysis of Iso-Seq and RNA-seq data reveals transcriptome complexity and differential isoform in skin tissues of different hair length Yak

The hair follicle development process is regulated by sophisticated genes and signaling networks, and the hair grows from the hair follicle. The Tianzhu white yak population exhibits differences in hair length, especially on the forehead and shoulder region. However, the genetic mechanism is still u...

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Bibliographic Details
Published in:BMC genomics 2024-05, Vol.25 (1), p.498-498, Article 498
Main Authors: Zhou, Xuelan, Wu, Xiaoyun, Pei, Chengfang, He, Meilan, Chu, Min, Guo, Xian, Liang, Chunnian, Bao, Pengjia, Yan, Ping
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Alternative Splicing
Analysis
Animals
Annotations
Cattle - genetics
Complexity
Differential isoforms
Extracellular matrix
Fibroblast growth factor 5
Fibroblast growth factors
Forehead
Gene expression
Gene Expression Profiling
Genes
Genetic aspects
Genomes
Hair
Hair - growth & development
Hair - metabolism
Hair Follicle - growth & development
Hair Follicle - metabolism
Hair length
Identification and classification
Insulin-like growth factor II receptors
Insulin-like growth factor-binding protein 5
Isoform sequencing
Isoforms
Molecular modelling
Polyadenylation
Protein interaction
Protein Isoforms - genetics
Protein Isoforms - metabolism
Protein-protein interactions
Proteins
Ribonucleic acid
RNA
RNA sequencing
RNA-Seq
Sequence Analysis, RNA
Shoulder
Signal transduction
Skin
Skin - metabolism
Software
Textile industry
Tianzhu white yak
Transcriptome
Transcriptomes
Wool
Yaks
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Summary:The hair follicle development process is regulated by sophisticated genes and signaling networks, and the hair grows from the hair follicle. The Tianzhu white yak population exhibits differences in hair length, especially on the forehead and shoulder region. However, the genetic mechanism is still unclear. Isoform sequencing (Iso-seq) technology with advantages in long reads sequencing. Hence, we combined the Iso-seq and RNA-seq methods to investigate the transcript complexity and difference between long-haired yak (LHY) and normal-haired yak (NHY). The hair length measurement result showed a significant difference between LHY and NHY on the forehead and the shoulder (P-value 
ISSN:1471-2164
1471-2164
DOI:10.1186/s12864-024-10345-8