Acute Effect of a Protein Supplement on Targeted Plasma Amino Acid Profile among Healthy Asian Indians: A Randomized Controlled Trial

Background. Indians have a poor protein intake in terms of quantity as well as quality because of their predominantly cereal-based diet. However, there is limited information on circulatory amino acid levels in healthy Indians. Herein, we evaluated the acute effect of a protein supplement on the pla...

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Published in:Journal of nutrition and metabolism 2020, Vol.2020 (2020), p.1-9
Main Authors: Sucharita, Sambashivaiah, Selvam, Sumithra, Joshi, Nandan, Marathe, Madhavi, Sharma, Nidhi, Kurien, Ammu, Devi, Sarita
Format: Article
Language:English
Subjects:
Amino acids
Analysis
Anemia
Cereals
Clinical trials
Diabetes
Diet
Dietary supplements
Exercise
Food
Liquid chromatography
Mass spectrometry
Mass spectroscopy
Milk
Muscle function
Musculoskeletal system
Physical fitness
Plasma
Plasma levels
Protein synthesis
Proteins
Quality
Questionnaires
Statistical analysis
Studies
Type 2 diabetes
Womens health
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Summary:Background. Indians have a poor protein intake in terms of quantity as well as quality because of their predominantly cereal-based diet. However, there is limited information on circulatory amino acid levels in healthy Indians. Herein, we evaluated the acute effect of a protein supplement on the plasma levels of essential amino acids (EAAs) in healthy Indian adults, using targeted EAA analysis. Methods. In this double-blind, randomized, crossover study, 20 healthy Indian adults were randomized to receive the test protein supplement (treatment arm, n = 10) or placebo (control arm, n = 10) with milk, after overnight fasting. After 7 days, the participants returned for the crossover treatment. Blood samples were collected at baseline and at 60 and 120 min after protein/placebo consumption. Plasma EAA levels were estimated using liquid chromatography-tandem mass spectrometry. Repeated measures ANOVA was performed to assess the effect of treatment on EAA levels. P values 
ISSN:2090-0724
2090-0732
DOI:10.1155/2020/8946820