Marine Microorganism Molecules as Potential Anti-Inflammatory Therapeutics

The marine environment represents a formidable source of biodiversity, is still largely unexplored, and has high pharmacological potential. Indeed, several bioactive marine natural products (MNPs), including immunomodulators, have been identified in the past decades. Here, we review how this reservo...

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Bibliographic Details
Published in:Marine drugs 2024-09, Vol.22 (9), p.405
Main Authors: Lasalo, Malia, Jauffrais, Thierry, Georgel, Philippe, Matsui, Mariko
Format: Article
Language:English
Subjects:
Animals
anti-inflammatory
Anti-Inflammatory Agents - pharmacology
Antibodies
Aquatic Organisms
Arthritis
B cells
Biodiversity
Biological activity
Biological Products - pharmacology
Biological Products - therapeutic use
Cytokines
Disease
Gene expression
Humans
Immunomodulation
Immunomodulators
Inflammation
Inflammation - drug therapy
Inflammatory bowel disease
Kinases
Life Sciences
Marine biology
Marine environment
Marine microorganisms
Microorganisms
MNPs
Natural products
Pharmaceuticals
Phosphorylation
Proteins
Review
Rheumatoid arthritis
Rheumatoid factor
Transcription factors
Tumor necrosis factor-TNF
Ulcerative colitis
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Summary:The marine environment represents a formidable source of biodiversity, is still largely unexplored, and has high pharmacological potential. Indeed, several bioactive marine natural products (MNPs), including immunomodulators, have been identified in the past decades. Here, we review how this reservoir of bioactive molecules could be mobilized to develop novel anti-inflammatory compounds specially produced by or derived from marine microorganisms. After a detailed description of the MNPs exerting immunomodulatory potential and their biological target, we will briefly discuss the challenges associated with discovering anti-inflammatory compounds from marine microorganisms.
ISSN:1660-3397
1660-3397
DOI:10.3390/md22090405