Interactions of Oxytocin and Dopamine-Effects on Behavior in Health and Disease

The hypothalamic neuropeptide and hormone oxytocin are of fundamental importance for maternal, social, and sexual behavior. Deviations in oxytocin levels have also been associated with anxiety, autism spectrum disorders (ASD), depression, ADHD (attention deficit hyperactivity disorder), and schizoph...

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Bibliographic Details
Published in:Biomedicines 2024-10, Vol.12 (11), p.2440
Main Authors: Petersson, Maria, Uvnäs-Moberg, Kerstin
Format: Article
Language:English
Subjects:
Attention deficit hyperactivity disorder
Autism
behavior
Biochemistry and Molecular Biology
Biokemi och molekylärbiologi
Cardiac glycosides
Cardiotonic agents
Catecholamines
depression
Dopamine
feeding
Hormones
Hypothalamus
Läkemedelskemi
Maternal behavior
Medicinal Chemistry
Mental disorders
Nervous system
Nobel prizes
Oxytocin
Phenols
Pituitary hormones
Review
Schizophrenia
Sex
Sexual behavior
Social behavior
Social interaction
Spinal cord
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Summary:The hypothalamic neuropeptide and hormone oxytocin are of fundamental importance for maternal, social, and sexual behavior. Deviations in oxytocin levels have also been associated with anxiety, autism spectrum disorders (ASD), depression, ADHD (attention deficit hyperactivity disorder), and schizophrenia. Both oxytocin and dopamine are often considered reward- and feel-good hormones, and dopamine is associated with the above-mentioned behaviors and, and dopamine is also associated with the above-mentioned behaviors and disorders. Although being structurally totally different, oxytocin, a peptide, and dopamine, a monoamine, they have a number of similar effects. They are synthesized both in the brain and in the periphery, and they affect each other's release and receptors. In addition, oxytocin and dopamine are released in response to, for example, social interaction, sex, feeding, and massage. This review discusses interactions between oxytocin and dopamine with a specific focus on behavioral effects and possible roles of oxytocin and dopamine in various mental disorders and functional diversities.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines12112440