The prognostic and clinicopathological significance of PD-L1 expression in patients with diffuse large B-cell lymphoma: a meta-analysis

• Published in: BMC cancer 2019-03, Vol.19 (1), p.273-273, Article 273
• Main Authors: Qiu, Liping, Zheng, Hanlu, Zhao, Xiaoying
• Format: Article
• Language: English
• Subjects: Apoptosis; B-cell lymphoma; B7-H1 Antigen - metabolism; Bcl-6 protein; Biomarkers, Tumor - metabolism; Cancer; Care and treatment; Cell death; Diagnosis; Diffuse large B-cell lymphoma; Female; Gene expression; Gene Expression Regulation, Neoplastic; Humans; Interferon Regulatory Factors - metabolism; Kinases; Ligands; Lymphocytes B; Lymphocytic leukemia; Lymphoma; Lymphoma, Large B-Cell, Diffuse - metabolism; Lymphoma, Large B-Cell, Diffuse - pathology; Male; Measurement techniques; Medical prognosis; Meta-analysis; Odds Ratio; PD-L1 protein; Prognosis; Programmed cell death receptor 1 ligand 1 (PD-L1); Proto-Oncogene Proteins c-bcl-6 - metabolism; Sensitivity analysis; Studies; Survival Analysis; Tumor cells; Tumors
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-019-5466-y

Programmed cell death receptor 1 ligand 1 (PD-L1) expression in various tumors, including hematologic malignancies, has recently become a research topic of great interest. We performed a meta-analysis to evaluate the prognostic and clinicopathological value of PD-L1 expressed in tumor cells of patients with diffuse large B-cell lymphoma (DLBCL). Relevant studies were identified from PubMed, EMBASE, Web of Science and the Cochrane Library. The hazard ratio (HR) and 95% confidence interval (95% CI) were used for analyzing survival outcomes, and the odds ratio (OR) was used for analyzing clinicopathological parameters. Pooled results showed that tumor cell PD-L1 expression is associated with poor overall survival (OS) (HR = 2.128, 95% CI: 1.341-3.378, P = 0.001), the non-germinal center B-cell-like subtype (OR = 2.891, 95% CI: 2.087-4.003, P